Ca2+ Signaling in Exocrine Cells

被引：10

作者：

Ahuja, Malini ^{[1
]}

Chung, Woo Young ^{[1
]}

Lin, Wei-Yin ^{[1
]}

McNally, Beth A. ^{[1
]}

Muallem, Shmuel ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Epithelial Signaling & Transport Sect, NIH, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2020年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

MEMBRANE CONTACT SITES; PROTEIN-KINASE-A; ENDOPLASMIC-RETICULUM; FLUID SECRETION; 2-PORE CHANNELS; CRAC CHANNELS; POLARIZED EXPRESSION; PHOSPHATIDIC-ACID; RECEPTOR-ACTIVITY; TRPC CHANNELS;

D O I：

10.1101/cshperspect.a035279

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium (Ca2+) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion. This physiological process requires the organization of the two signaling pathways into complexes at defined cellular domains and close placement. Such domains are formed by membrane contact sites (MCS). This review discusses the basic properties of Ca2+ signaling in exocrine cells, the role of MCS in the organization of cell signaling and in cross talk and synergism between the Ca2+ and cAMP signaling pathways and, finally, the mechanism by which the Ca2+ and cAMP pathways synergize to stimulate epithelial fluid and electrolyte secretion.

引用

页数：14

共 50 条

[11] Altered Ca2+ signaling in enamelopathies
Eckstein, Miriam
Aulestia, Francisco J.
Nurbaeva, Meerim K.
Lacruz, Rodrigo S.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2018, 1865 (11): : 1778 - 1785
[12] Ca2+ Signaling in Oligodendrocyte Development
Zhang, Ming
Liu, Yuming
Wu, Shengxi
Zhao, Xianghui
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019, 39 (08) : 1071 - 1080
[13] Stim and Orai proteins in neuronal Ca2+ signaling and excitability
Moccia, Francesco
Zuccolo, Estella
Soda, Teresa
Tanzi, Franco
Guerra, Germano
Mapelli, Lisa
Lodola, Francesco
D'Angelo, Egidio
FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
[14] Exocytosis, dependent on Ca2+ release from Ca2+ stores, is regulated by Ca2+ microdomains
Low, Jiun T.
Shukla, Alka
Behrendorff, Natasha
Thorn, Peter
JOURNAL OF CELL SCIENCE, 2010, 123 (18) : 3201 - 3208
[15] Ca2+ signaling and regulation of fluid secretion in salivary gland acinar cells
Ambudkar, Indu S.
CELL CALCIUM, 2014, 55 (06) : 297 - 305
[16] Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
La Rovere, Rita M. L.
Roest, Gemma
Bultynck, Geert
Parys, Jan B.
CELL CALCIUM, 2016, 60 (02) : 74 - 87
[17] CFTR and Ca2+ signaling in cystic fibrosis
Antigny, Fabrice
Norez, Caroline
Becq, Frederic
Vandebrouck, Clarisse
FRONTIERS IN PHARMACOLOGY, 2011, 2
[18] Ca2+ signaling, genes and the cell cycle
Machaca, Khaled
CELL CALCIUM, 2011, 49 (05) : 323 - 330
[19] Homer proteins in Ca2+ signaling by excitable and non-excitable cells
Worley, Paul F.
Zeng, Weizhong
Huang, Guojin
Kim, Joo Young
Shin, Dong Min
Kim, Min Seuk
Yuan, Joseph P.
Kiselyov, Kirill
Muallem, Shmuel
CELL CALCIUM, 2007, 42 (4-5) : 363 - 371
[20] Ca2+ signaling, genes and the cell cycle
Machaca, Khaled
CELL CALCIUM, 2010, 48 (05) : 243 - 250

← 1 2 3 4 5 →