Ca2+ Signaling in Exocrine Cells

被引：10
|
作者：
Ahuja, Malini [1 ]
Chung, Woo Young [1 ]
Lin, Wei-Yin [1 ]
McNally, Beth A. [1 ]
Muallem, Shmuel [1 ]
机构：
[1] Natl Inst Dent & Craniofacial Res, Epithelial Signaling & Transport Sect, NIH, Bethesda, MD 20892 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2020年 / 12卷 / 05期
基金：
美国国家卫生研究院;
关键词：
MEMBRANE CONTACT SITES; PROTEIN-KINASE-A; ENDOPLASMIC-RETICULUM; FLUID SECRETION; 2-PORE CHANNELS; CRAC CHANNELS; POLARIZED EXPRESSION; PHOSPHATIDIC-ACID; RECEPTOR-ACTIVITY; TRPC CHANNELS;
D O I：
10.1101/cshperspect.a035279
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium (Ca2+) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion. This physiological process requires the organization of the two signaling pathways into complexes at defined cellular domains and close placement. Such domains are formed by membrane contact sites (MCS). This review discusses the basic properties of Ca2+ signaling in exocrine cells, the role of MCS in the organization of cell signaling and in cross talk and synergism between the Ca2+ and cAMP signaling pathways and, finally, the mechanism by which the Ca2+ and cAMP pathways synergize to stimulate epithelial fluid and electrolyte secretion.
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收藏
页数：14
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