An Efficient Synthesis of Acenaphtho[1,2-b]indole Derivatives via Domino Reaction

被引：5

作者：

Zhang, Guo-Ning ^{[1
,2
]}

Yuan, Xia ^{[3
]}

Niu, Weiping ^{[1
,2
]}

Zhu, Mei ^{[1
,2
]}

Wang, Juxian ^{[1
,2
]}

Wang, Yucheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 11期

基金：

中国国家自然科学基金;

关键词：

acenaphtho[1; 2-b]indole; domino reaction; enaminone; acenaphthoquinone; l-proline; MULTICOMPONENT SYNTHESIS; SELECTIVE SYNTHESIS; INDOLES;

D O I：

10.3390/molecules23113045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A concise and efficient synthesis of acenaphtho[1,2-b]indole derivatives via the domino reactions of enaminones with acenaphthoquinone catalyzed by l-proline has been developed. This protocol has the advantages of good yields, operational convenience and high regioselectivity.

引用

页数：9

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