Visualizing Kinetically Robust Co4IIIL6 Assemblies in Vivo: SPECT Imaging of the Encapsulated [99mTc]TcO4- Anion

被引：94

作者：

Burke, Benjamin P. ^{[2
,4
]}

Grantham, William ^{[1
]}

Burke, Michael J. ^{[1
]}

Nichol, Gary. S. ^{[1
]}

Roberts, David ^{[3
,4
]}

Renard, Isaline ^{[2
,4
]}

Hargreaves, Rebecca ^{[2
,4
]}

Cawthorne, Christopher ^{[3
,4
]}

Archibald, Stephen J. ^{[2
,4
]}

Lusby, Paul J. ^{[1
]}

机构：

[1] Univ Edinburgh, EaStCHEM Sch Chem, Joseph Black Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland

[2] Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England

[3] Univ Hull, Sch Life Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England

[4] Univ Hull, Positron Emiss Tomog Res Ctr, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 49期

基金：

英国工程与自然科学研究理事会;

关键词：

ANTICANCER ACTIVITY; CHELATOR DESIGN; DIELS-ALDER; EFFICIENT; CATALYSIS; CAGES; RADIOPHARMACEUTICALS; WATER; METALLACYCLES; NANOPARTICLES;

D O I：

10.1021/jacs.8b09582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under non equilibrium conditions. Using a kinetically robust (Co4L6)-L-III tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the y-emitting [Tc-99m]TcO4- anion, under conditions compatible with in vivo administration. Subsequent single-photon emission computed tomography imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

引用

页码：16877 / 16881

页数：5

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