Less Invasive Surfactant Administration in Very Prematurely Born Infants

被引:10
作者
Shetty, Sandeep [1 ,2 ]
Egan, Helen [1 ]
Cornuaud, Peter [1 ]
Kulkarni, Anay [1 ,2 ]
Duffy, Donovan [1 ,2 ]
Greenough, Anne [3 ,4 ,5 ,6 ]
机构
[1] St Georges Univ Hosp NHS Fdn Trust, Neonatal Intens Care Ctr, London, England
[2] St Georges Univ London, Dept Neonatal Med, London, England
[3] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Women & Childrens Hlth, London, England
[4] Kings Coll London, Asthma UK Ctr Allerg Mech Asthma, London, England
[5] Guys & St Thomas NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
[6] Kings Coll London, London, England
来源
AJP REPORTS | 2021年 / 11卷 / 03期
基金
英国医学研究理事会;
关键词
less invasive surfactant administration; LISA; surfactant administration; BPD; duration of mechanical ventilation; length of hospital stay; RESPIRATORY-DISTRESS-SYNDROME; BREATHING PRETERM INFANTS; CATHETER;
D O I
10.1055/s-0041-1735632
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background Less invasive surfactant administration (LISA) is the preferred mode of surfactant administration for spontaneously breathing preterm babies supported by noninvasive ventilation (NIV). Objective The aim of this study was to determine whether LISA on the neonatal unit or in the delivery suite was associated with reduced rates of bronchopulmonary dysplasia (BPD) or the need for intubation, or lower durations of invasive ventilation and length of hospital stay (LOS). Methods A historical comparison was undertaken. Each "LISA" infant was matched with two infants (controls) who did not receive LISA. Results The 25 LISA infants had similar gestational ages and birth weights to the 50 controls (28 [25.6-31.7] weeks vs. 28.5 [25.4-31.9] weeks, p =0.732; 1,120 (580-1,810) g vs. 1,070 [540-1,869] g, p = 0.928), respectively. USA infants had lower requirement for intubation (52 vs. 90%, p < 0.001), shorter duration of invasive ventilation (median 1 [0-35] days vs. 6 [0-62] days p = 0.001) and a lower incidence of BPD (36 vs. 64%, p = 0.022). There were no significant differences in duration of NIV (median 26 [3-225] vs. 23 [2-85] days, p = 0.831) or the total LOS (median 76 [24-259] vs. 85 [27-221], p = 0.238). Conclusion LISA on the neonatal unit or the delivery suite was associated with a lower BPD incidence, need for intubation, and duration of invasive ventilation.
引用
收藏
页码:e119 / e122
页数:4
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