The effect of pharmacological treatment and lifestyle modification in patients with nonalcoholic fatty liver disease: An umbrella review of meta-analyses of randomized controlled trials

被引：16

作者：

Cho, Kyuyeon ^{[1
]}

Park, Seoyeon ^{[1
]}

Koyanagi, Ai ^{[2
,3
]}

Jacob, Louis ^{[2
,4
]}

Yon, Dong Keon ^{[4
]}

Lee, Seung Won ^{[5
,6
]}

Kim, Min Seo ^{[7
]}

Kim, Seung Up ^{[8
,9
,10
]}

Kim, Beom Kyung ^{[8
,9
,10
]}

Shin, Jae Il ^{[11
]}

Smith, Lee ^{[12
]}

机构：

[1] Yonsei Univ, Coll Med, Seoul, South Korea

[2] ICREA, Barcelona, Spain

[3] Univ Versailles St Quentinen Yvelines, Fac Med, Montigny Le Bretonneux, France

[4] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Pediat, Coll Med, Seoul, South Korea

[5] Sejong Univ, Dept Data Sci, Coll Software Convergence, Seoul, South Korea

[6] Sungkyunkwan Univ, Sch Med, Suwon, South Korea

[7] Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[8] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[9] Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea

[10] Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea

[11] Yonsei Univ, Dept Pediat, Coll Med, 50-1 Yonsei Ro,CPO Box 8044, Seoul 03722, South Korea

[12] Anglia Ruskin Univ, Cambridge Ctr Hlth Performance & Wellbeing, Cambridge, England

来源：

OBESITY REVIEWS | 2022年 / 23卷 / 09期

关键词：

meta-analysis; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; randomized controlled study; BARIATRIC SURGERY; VITAMIN-D; NAFLD; STEATOHEPATITIS; SUPPLEMENTATION; EFFICACY;

D O I：

10.1111/obr.13464

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a liver disease that affects approximately 25% of the world's population, and various treatments have been applied for NAFLD patients. We compared the effectiveness of each intervention conducted to treat NAFLD by evaluating meta-analyses of pharmacological interventions and lifestyle modification including diet and exercise. We searched Pubmed/Medline, Embase, and Cochrane Library and included meta-analyses of randomized controlled trials investigating the effects of pharmacological intervention and lifestyle modification on NAFLD. The quality of included meta-analyses was evaluated by AMSTAR-2. If the effect size was expressed as mean difference, it was converted to standardized mean difference based on the random-effects model. A total of 1694 meta-analyses were identified, and 27 meta-analyses were eventually included in the review. Regarding pharmacological interventions, there was a high strength of evidence for the ALT reduction effect of silymarin on inactive controls (SMD = 0.88, p < 0.01, seven trials, 518 participants). Meanwhile, it was confirmed that appropriate diet and exercise were important in reducing liver fat (SMD = 1.51, p < 0.01, 12 trials, 765 participants). This umbrella review assessed the effects of pharmacological interventions and lifestyle modifications in the treatment of NAFLD. The results of this review can be utilized for clinical decisions when treating NAFLD patients.

引用

页数：11

共 46 条

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