An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

被引：26
|
作者：
Liang, Zizhen [1 ]
Zhang, Tiantian [1 ]
Zhang, Xiaoqian [1 ]
Zhang, Jia [1 ]
Zhao, Changqi [1 ]
机构：
[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China
来源：
MOLECULES | 2015年 / 20卷 / 01期
基金：
美国国家科学基金会;
关键词：
Diphylleia sinensis L; Aspergillus fumigates; indolediketopiperazine alkaloids; steroid; cytotoxicity; METABOLITES; ACID;
D O I：
10.3390/molecules20011424
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.
引用
收藏
页码：1424 / 1433
页数：10
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