An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

被引：26

作者：

Liang, Zizhen ^{[1
]}

Zhang, Tiantian ^{[1
]}

Zhang, Xiaoqian ^{[1
]}

Zhang, Jia ^{[1
]}

Zhao, Changqi ^{[1
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Regulat Biol, Beijing 100875, Peoples R China

来源：

MOLECULES | 2015年 / 20卷 / 01期

基金：

美国国家科学基金会;

关键词：

Diphylleia sinensis L; Aspergillus fumigates; indolediketopiperazine alkaloids; steroid; cytotoxicity; METABOLITES; ACID;

D O I：

10.3390/molecules20011424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.

引用

收藏

页码：1424 / 1433

页数：10

相关论文

共 21 条

[1] 12,13-DIHYDROXY-FUMITREMORGIN-C FROM ASPERGILLUS-FUMIGATUS [J].

ABRAHAM, WR ;

ARFMANN, HA .

PHYTOCHEMISTRY, 1990, 29 (03) :1025-1026

[2] Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen [J].

Boot, Claudia M. ;

Gassner, Nadine C. ;

Compton, Jennifer E. ;

Tenney, Karen ;

Tamble, Craig M. ;

Lokey, R. Scott ;

Holman, Theodore R. ;

Crews, Phillip .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (10) :1672-1675

[3] MYCOTOXINS PRODUCED BY ASPERGILLUS-FUMIGATUS SPECIES ISOLATED FROM MOLDED SILAGE [J].

COLE, RJ ;

KIRKSEY, JW ;

DORNER, JW ;

WILSON, DM ;

JOHNSON, JC ;

JOHNSON, AN ;

BEDELL, DM ;

SPRINGER, JP ;

CHEXAL, KK ;

CLARDY, JC ;

COX, RH .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1977, 25 (04) :826-830

[4] Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus .1. Taxonomy, fermentation, isolation and biological properties [J].

Cui, CB ;

Kakeya, H ;

Okada, G ;

Onose, R ;

Osada, H .

JOURNAL OF ANTIBIOTICS, 1996, 49 (06) :527-533

[5] NMR-STUDY OF SOME ANTHRAQUINONES FROM RHUBARB [J].

DANIELSEN, K ;

AKSNES, DW .

MAGNETIC RESONANCE IN CHEMISTRY, 1992, 30 (04) :359-360

[6] Chaetoglobins A and B, two unusual alkaloids from endophytic Chaetomium globosum culture [J].

Ge, Hui Ming ;

Zhang, Wei Yun ;

Ding, Gang ;

Saparpakorn, Patchareenart ;

Song, Yong Chun ;

Hannongbua, Supa ;

Tan, Ren Xiang .

CHEMICAL COMMUNICATIONS, 2008, (45) :5978-5980

[7] Bioactive Alkaloids from Endophytic Aspergillus fumigatus [J].

Ge, Hui Ming ;

Yu, Zhi Guo ;

Zhang, Jie ;

Wu, Jun Hua ;

Tan, Ren Xiang .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (04) :753-755

[8] Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus [J].

Kato, Naoki ;

Suzuki, Hirokazu ;

Takagi, Hiroshi ;

Uramoto, Masakazu ;

Takahashi, Shunji ;

Osada, Hiroyuki .

CHEMBIOCHEM, 2011, 12 (05) :711-714

[9] Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin [J].

Kusari, S. ;

Lamshoeft, M. ;

Spiteller, M. .

JOURNAL OF APPLIED MICROBIOLOGY, 2009, 107 (03) :1019-1030

[10] Identification of novel derivative of helvolic acid from Metarhizium anisopliae grown in medium with insect component [J].

Lee, Si-Young ;

Kinoshita, Hiroshi ;

Ihara, Fumio ;

Igarashi, Yasuhiro ;

Nihira, Takuya .

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2008, 105 (05) :476-480