ASPECTS OF ANIMAL MODELS FOR MAJOR NEUROPSYCHIATRIC DISORDERS

被引：11

作者：

Lefter, Radu ^{[1
]}

Cojocaru, Dumitru ^{[1
,2
]}

Ciobica, Alin ^{[1
]}

Paulet, Ioan Manuel ^{[1
]}

Serban, Ionela Lacramioara ^{[3
]}

Anton, Emil ^{[3
]}

机构：

[1] Alexandru Ioan Cuza Univ, Iasi 700506, Romania

[2] Romanian Acad, Ctr Biomed Res, Iasi Branch, Bucharest, Romania

[3] Gr T Popa Univ Med & Pharm, Iasi 700115, Romania

来源：

ARCHIVES OF BIOLOGICAL SCIENCES | 2014年 / 66卷 / 03期

关键词：

animal models; neuropsychiatric disorders; INDUCED MEMORY IMPAIRMENT; OXIDATIVE STRESS STATUS; SCHIZOPHRENIA; SYSTEM; BRAIN; PHENCYCLIDINE; ANTAGONIZES; SCOPOLAMINE; ACTIVATION; DEPRESSION;

D O I：

10.2298/ABS1403105L

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We will review the main animal models for the major neuropsychiatric disorders, focusing on schizophrenia, Alzheimer's disease, Parkinson's disease, depression, anxiety and autism. Although these mental disorders are specifically human pathologies and therefore impossible to perfectly replicate in animals, the use of experimental animals is based on the physiological and anatomical similarities between humans and animals such as the rat, and mouse, and on the fact that 99% of human and murine genomes are shared. Pathological conditions in animals can be assessed by manipulating the metabolism of neurotransmitters, through various behavioral tests, and by determining biochemical parameters that can serve as important markers of disorders.

引用

页码：1105 / 1115

页数：11

共 45 条

[31] The effects of a 6-OHDA induced lesion in murine nuccleus accumbens on memory and oxidative stress status [J].