Delivering nitric oxide with nanoparticles

被引：130

作者：

Quinn, John F. ^{[1
]}

Whittaker, Michael R. ^{[1
]}

Davis, Thomas P. ^{[1
,2
]}

机构：

[1] Monash Univ, ARC Ctr Excellence Convergent Bionano Sci & Techn, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

JOURNAL OF CONTROLLED RELEASE | 2015年 / 205卷

基金：

澳大利亚研究理事会;

关键词：

Nanoparticle; Nitric oxide; Gasotransmitter; Therapy; SUSTAINED-RELEASE; DENDRIMERS; INHIBITION; EFFICACY; INVOLVEMENT; SYNTHASE; BIOFILMS; PLATFORM; VEHICLE; SHAPE;

D O I：

10.1016/j.jconrel.2015.02.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While best known for its important signalling functions in human physiology, nitric oxide is also of considerable therapeutic interest. As such, nanoparticle-based systems which enable the sustained exogenous delivery of nitric oxide have been the subject of considerable investigation in recent years. Herein we review the various nanoparticle systems that have been used to date for nitric oxide delivery, and explore the array of potential therapeutic applications that have been reported. Specifically, we discuss the modification of sol-gel based silica particles, functionalised metal/metal oxide nanoparticles, polymer-coated metal nanoparticles, dendrimers, micelles and star polymers to impart nitric oxide release capability. We also consider the various areas in which therapeutic applications are envisaged: wound healing, antimicrobial applications, cardiovascular treatments, sexual medicine and cancer treatment. Finally, we discuss possible future directions for this versatile and potentially important technology. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：190 / 205

页数：16

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