Rational design of shear-thinning supramolecular hydrogels with porphyrin for controlled chemotherapeutics release and photodynamic therapy

被引：25
作者：
Jin, Hua [1 ]
Dai, Xiao-Hui [1 ,2 ]
Wu, Chuan [1 ]
Pan, Jian-Ming [1 ]
Wang, Xiao-Hong [1 ]
Yan, Yong-Sheng [1 ,2 ]
Liu, Dong-Ming [3 ]
Sun, Lin [4 ]
机构：
[1] Jiangsu Univ, Dept Chem Engn, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[3] Jiangsu Univ, Hosp Affiliated, Zhenjiang 212013, Peoples R China
[4] CSR Qingdao Sifang Co Ltd, Qingdao 266111, Shandong, Peoples R China
来源：
EUROPEAN POLYMER JOURNAL | 2015年 / 66卷
基金：
中国国家自然科学基金;
关键词：
Shear-thinning; Supramolecular hydrogels; Photodynamic therapy; Drug delivery; Block copolymer; ALPHA-CYCLODEXTRIN; COMPLEX-FORMATION; INCLUSION COMPLEXATION; TRIBLOCK COPOLYMERS; DIBLOCK COPOLYMER; DRUG-DELIVERY; MICELLES; POLY(EPSILON-CAPROLACTONE); CELLS; AGGREGATION;
D O I：
10.1016/j.eurpolymj.2015.01.047
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
An amphiphilic porphyrin-cored, star-shaped poly (epsilon-caprolactone)-b-poly (ethylene glycol) (SPPCL-b-PEG) copolymer was synthesized and used as a building block for constructing supramolecular hydrogels. With the aid of alpha-cyclodextrin (alpha-CD), thixotropic and reversible supramolecular hydrogel could be formed by copolymers based on the host-guest inclusion complexation (IC). Due to the biodegradable and biocompatible properties, this IC-based supramolecular hydrogel was used as carrier for doxorubicin (DOX) delivery systems. The release results presented a triphasic drug-release profile and the release of this system lasted more than 3 weeks. Also, upon irradiation with light (650 nm), cytotoxic singlet oxygen (O-1(2)) could be generated by porphyrin core and easily released from hydrogel matrix. Considering that both sustained-release drug delivery of hydrogels and porphyrin for photodynamic therapy (PDT) were achieved in a combined compound, this shear-thinning supramolecular hydrogel with porphyrin was elaborately designed as a promising replacement therapy to medium or advanced cancer for surgery. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：149 / 159
页数：11
相关论文
共 41 条
[1]   Supramolecular gels 'in action' [J].
Banerjee, Supratim ;
Das, Rajat K. ;
Maitra, Uday .
JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (37) :6649-6687
[2]   PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release [J].
Bhattarai, N ;
Ramay, HR ;
Gunn, J ;
Matsen, FA ;
Zhang, MQ .
JOURNAL OF CONTROLLED RELEASE, 2005, 103 (03) :609-624
[3]   Synthesis, characterization, effect of architecture on crystallization, and spherulitic growth of poly(L-lactide)-b-poly(ethylene oxide) copolymers with different branch arms [J].
Cai, C ;
Wang, L ;
Dong, CM .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2006, 44 (06) :2034-2044
[4]   Fabrication of star-shaped, thermo-sensitive poly(N-isopropylacrylamide)-cholic acid-poly(ε-caprolactone) copolymers and their self-assembled micelles as drug carriers [J].
Chen, Wen-Qin ;
Wei, Hua ;
Li, Song-Lin ;
Feng, Jun ;
Nie, Jun ;
Zhang, Xian-Zheng ;
Zhuo, Ren-Xi .
POLYMER, 2008, 49 (18) :3965-3972
[5]  
Dai X-H, 2014, NEW J CHEM
[6]   Supramolecular and biomimetic polypseudorotaxane/glycopolymer biohybrids: Synthesis, glucose-surfaced nanoparticles, and recognition with lectin [J].
Dai, Xiao-Hui ;
Dong, Chang-Ming ;
Yan, Deyue .
JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (12) :3644-3652
[7]   Supramolecular polypseudorotaxanes composed of star-shaped porphyrin-cored poly(ε-caprolactone) and α-cyclodextrin [J].
Dai, Xiao-Hui ;
Dong, Chang-Ming ;
Fa, Huan-Bao ;
Yan, Deyue ;
Wei, Yen .
BIOMACROMOLECULES, 2006, 7 (12) :3527-3533
[8]   Hydrogels for tissue engineering: scaffold design variables and applications [J].
Drury, JL ;
Mooney, DJ .
BIOMATERIALS, 2003, 24 (24) :4337-4351
[9]  
Feng Z., 2014, Journal of Applied Polymer Science, V131
[10]   COMPLEX-FORMATION BETWEEN POLY(ETHYLENE GLYCOL) AND ALPHA-CYCLODEXTRIN [J].
HARADA, A ;
KAMACHI, M .
MACROMOLECULES, 1990, 23 (10) :2821-2823
12345