PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions

被引：45
|
作者：
De Felici, Massimo [1 ]
Klinger, Francesca Gioia [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 18期
关键词：
primordial germ cells; PI3K; PTEN; AKT; ovarian follicles; ovarian reserve; primordial follicles; ovarian dysfunction; germ cell tumors; C-KIT PROTEIN; OOCYTE GROWTH; MOUSE OOCYTES; DNA-DAMAGE; FOLLICULAR DEVELOPMENT; EXPRESSION PATTERN; LIGAND; ACTIVATION; FOLLICLES; SURVIVAL;
D O I：
10.3390/ijms22189838
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the dynamics of the ovarian primordial follicle reserve and how dysregulation of these signaling pathways may contribute to the development of some types of germ cell tumors and ovarian dysfunctions.
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页数：13
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