Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

被引：54

作者：

Fan, Jun-Ting ^{[1
,2
]}

Chen, Yi-Shan ^{[1
,2
]}

Xu, Wen-Yan ^{[1
,2
,3
]}

Du, Liangcheng ^{[3
]}

Zeng, Guang-Zhi ^{[1
]}

Zhang, Yu-Mei ^{[1
]}

Su, Jia ^{[1
]}

Li, Yan ^{[1
]}

Tan, Ning-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 52期

基金：

中国国家自然科学基金;

关键词：

Rubia yunnanensis; Rubiyunnanin A; Rubiyunnanin B; Cyclopeptides; Cytotoxicity; Inhibition of NO production; CYTOTOXIC BICYCLIC HEXAPEPTIDES; RA;

D O I：

10.1016/j.tetlet.2010.07.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6810 / 6813

页数：4

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