GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles

被引：14

作者：

Bloch, Miki ^{[1
,2
]}

Azem, Foad ^{[2
,3
]}

Aharonov, Inbar ^{[1
]}

Ben Avi, Irit ^{[1
]}

Yagil, Yaron ^{[1
]}

Schreiber, Shaul ^{[1
,2
]}

Amit, Ami ^{[2
,3
]}

Weizman, Abraham ^{[2
,4
,5
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Dept Psychiat, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Sourasky Med Ctr, Lis Womens Hosp, IVF Unit, IL-64239 Tel Aviv, Israel

[4] Felsenstein Med Res Ctr, Geha Mental Hlth Ctr, Petah Tiqwa, Israel

[5] Felsenstein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 01期

关键词：

In vitro fertilization; GnRH agonist; estradiol; progesterone; depression; anxiety; mood; WOMEN; HORMONES; MOOD; ENDOMETRIOSIS; PERIMENOPAUSE; IVF;

D O I：

10.1016/j.fertnstert.2010.07.1073

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters. (Fertil Steril (R) 2011; 95:307-9. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：307 / 309

页数：3

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