Chicken toll-like receptors and their role in immunity

被引：54

作者：

Kannaki, T. R. ^{[1
]}

Reddy, M. R. ^{[1
]}

Shanmugam, M. ^{[1
]}

Verma, P. C. ^{[2
]}

Sharma, R. P. ^{[1
]}

机构：

[1] Project Directorate Poultry, Hyderabad 500030, Andhra Pradesh, India

[2] Indian Vet Res Inst, Izatnagar 243122, Uttar Pradesh, India

来源：

WORLDS POULTRY SCIENCE JOURNAL | 2010年 / 66卷 / 04期

关键词：

toll-like receptors (TLRs); chicken; innate immunity; disease resistance; IN-SILICO IDENTIFICATION; GENE-EXPRESSION; FUNCTIONAL-CHARACTERIZATION; REAL-TIME; INNATE; TLR4; ACTIVATION; INFECTION; BOVINE; RECOGNITION;

D O I：

10.1017/S0043933910000693

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate innate immune responses to pathogens by recognizing structural motifs. In response to pathogen associated molecular patterns (PAMPs), TLRs induce the production of reactive oxygen and nitrogen intermediates (ROI and RNI), inflammatory cytokines and up regulate the expression of co-stimulatory molecules, subsequently initiating adaptive immunity. Ten chicken TLR genes have been identified and their association with various diseases has been ascertained. This review concerns chicken toll-like receptors, their structure, expression, signalling, and their role in innate and adaptive immunity and disease resistance. It is concluded that TLR genes could be used as molecular markers for genetic selection for the improvement of disease resistance and TLR agonists as potential adjuvants in future vaccines.

引用

页码：727 / 738

页数：12

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