Efficacy of intrapartum chemoprophylaxis less than 4 hours duration

被引:22
作者
Berardi, Alberto [1 ]
Rossi, Cecilia [1 ]
Biasini, Augusto [2 ]
Minniti, Simona [3 ]
Venturelli, Claudia
Ferrari, Fabrizio [3 ]
Facchinetti, Fabio [3 ]
机构
[1] Azienda Osped Univ Policlin Modena, Unita Operat Neonatol, I-41100 Modena, Italy
[2] Osped Civile M Bufalini, Unita Operat Terapia Intens Neonatale & Pediat, Cesena, Italy
[3] Azienda Osped Univ Policlin Modena, Unita Operat Ostetricia, I-41100 Modena, Italy
关键词
Group B streptococcus; intrapartum chemoprophylaxis; infant; sepsis; ampicillin; VERTICAL TRANSMISSION; PROPHYLAXIS; AMPICILLIN; DISEASE;
D O I
10.3109/14767058.2010.511347
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Methods. aEuro integral In prospective, cohort study, 167 infants born to 167 GBS culture-positive mothers without additional risk factors were enrolled. Cultures were collected both, at 10--24 h after birth (admission) and at discharge. Results. aEuro integral Among 137 infants born to mothers who received inadequate prophylaxis, 5 (3.6%%, C.I. == 0.5--6.8) were colonized (>= a parts per thousand yen1 sites) at admission, at discharge, or both, at admission and discharge. Eighty-two women received prophylaxis < 2 h before delivery and two infants (2.4%%) were colonized at discharge. Eighteen (60.0%%, C.I. == 42.5--77.5) of 30 infants who were not exposed to prophylaxis were colonized at admission or both, at admission and discharge. Colonization was significantly more frequent among infants born to untreated mothers with respect to infants born to women who received inadequate prophylaxis (either < 2 or < 4 h). Conclusions. aEuro integral In this selected group, inadequate prophylaxis significantly interrupted vertical colonization. This effect was evident even if prophylaxis started < 2 h before delivery.
引用
收藏
页码:619 / 625
页数:7
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