Do immune checkpoint inhibitors perform identically in patients with weight extremes?

被引：17

作者：

El Rassy, Elie ^{[1
]}

Ghosn, Marwan ^{[1
]}

Al Rassy, Nathalie ^{[2
,3
]}

Assi, Tarek ^{[1
,4
]}

Robert, Caroline ^{[5
,6
]}

机构：

[1] St Joseph Univ, Hotel Dieu France Univ Hosp, Dept Med Oncol, Fac Med, Beirut, Lebanon

[2] Univ Littoral Opal Coast ULCO, Lab Pathophysiol Inflammatory Bone Dis PMOI EA449, Boulogne Sur Mer, France

[3] Univ Lille, Lille, France

[4] Univ Paris Saclay, Inst Gustave Roussy, Dept Med Oncol, F-94805 Villejuif, France

[5] Inst Gustave Roussy, Dept Oncodermatol, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[6] Univ Paris Sud, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

来源：

IMMUNOTHERAPY | 2018年 / 10卷 / 09期

关键词：

anorexia; cachexia; immune checkpoint inhibitors; obesity; BONE-MARROW ADIPOCYTES; BODY-MASS INDEX; CANCER; IMMUNOTHERAPY; OBESITY; ADIPOSITY; BLOCKADE; CELLS;

D O I：

10.2217/imt-2018-0053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interaction between the two recent hallmarks of carcinogenesis, the immune system and energetic metabolism, has not been well investigated. The limited literature available on this topic describes a correlation between the efficacy and safety of immune checkpoint inhibitors with body mass index. A key knowledge gap is the understanding of this correlation as outcomes are strongly affected highlighting the need to prospective studies in this regard. This paper evaluates the rationale to these correlations at weight extremes and suggests the evaluation patient's weights and associated inflammatory profile before the initiation of immune checkpoint inhibition in cancer patients.

引用

页码：733 / 736

页数：4

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