Inflammation in cancer and depression: a starring role for the kynurenine pathway

被引：86

作者：

Sforzini, Luca ^{[1
,2
]}

Nettis, Maria Antonietta ^{[2
,3
,4
]}

Mondelli, Valeria ^{[2
,3
,4
]}

Pariante, Carmine Maria ^{[2
,3
,4
]}

机构：

[1] Univ Milan, Psychiat Unit, Dept Biomed & Clin Sci, ASST Fatebenefratelli Sacco Univ Hosp, Milan, Italy

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[3] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth & Res, Biomed Res Ctr, London, England

[4] Kings Coll London, London, England

来源：

PSYCHOPHARMACOLOGY | 2019年 / 236卷 / 10期

关键词：

Cancer; Chemotherapy; Depression; IDO inhibitors; Immunotherapy; Inflammation; Indoleamine; 2-3-dioxygenase; Kynurenine; QUALITY-OF-LIFE; INDOLEAMINE 2,3-DIOXYGENASE; INTERFERON-ALPHA; BREAST-CANCER; TRYPTOPHAN-METABOLISM; CYTOKINE PRODUCTION; PANCREATIC-CANCER; MENTAL-HEALTH; ALL-CAUSE; ASSOCIATION;

D O I：

10.1007/s00213-019-05200-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. A common biological mechanism, involving a dysregulated immune system, seems to underpin this comorbidity. In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases. As a consequence, targeting enzymes involved in this pathway offers a unique opportunity to develop new strategies to treat cancer and depression at once. In this work, we provide a systematic review of the evidence up to date on the kynurenine pathway role in linking depression and cancer and on clinical implications of this evidence. In particular, complications due to chemotherapy are discussed, as well as the potential antidepressant efficacy of novel immunotherapies for cancer.

引用

页码：2997 / 3011

页数：15

共 122 条

[1] Involvement of the Kynurenine Pathway in Human Glioma Pathophysiology [J].