A new hypothesis for how sex steroid hormones regulate bone mass

被引：33

作者：

Lorenzo, J ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Div Endocrinol L3104, Farmington, CT 06030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 111卷 / 11期

关键词：

D O I：

10.1172/JCI200318812

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been proposed - but remains controversial - that estrogen's effects on various tissues may be mediated by different cell signaling pathways. Researchers have identified (see related article beginning on page 1651) a synthetic ligand that activates only a subset of these pathways, suggesting that bypass of the traditional estrogen pathway can prevent bone loss without associated side effects on reproductive organs.

引用

页码：1641 / 1643

页数：3

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