Oral vaccination against bovine tuberculosis with Mycobacterium bovis BCG

被引:11
作者
Cross, Martin L. [1 ]
Aldwell, Frank [1 ]
机构
[1] Univ Otago, Immune Solut, Dunedin, New Zealand
关键词
BCG vaccine; bovine tuberculosis; livestock; oral vaccination; wildlife;
D O I
10.1586/14760584.6.3.323
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The use of a bacillus Calmette-Guerin (BCG)-based vaccine could represent a viable strategy for controlling bovine tuberculosis (TB), principally in those cases where a wildlife disease vector exists. This article focuses on recent progress in animal TB vaccinology, outlining that oral-route vaccination represents the most feasible means of distributing a vaccine to control disease in wildlife. Drawing on historical successes of previous wildlife vaccination programs, the article suggests how, and in what form, an oral-delivery BCG-based vaccine might become operational, considering the wide diversity of TB reservoir species and the inherent problems associated with field delivery of a live-attenuated microbial vaccine.
引用
收藏
页码:323 / 331
页数:9
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