Initial pulmonary metastasis after pancreatectomy for pancreatic ductal adenocarcinoma

被引：12

作者：

Shimizu, Tetsunosuke ^{[1
]}

Taniguchi, Kohei ^{[1
,2
]}

Asakuma, Mitsuhiro ^{[1
]}

Komeda, Koji ^{[1
]}

Inoue, Yoshihiro ^{[1
]}

Lee, Sang-Woong ^{[1
]}

Hirokawa, Fumitoshi ^{[1
]}

Uchiyama, Kazuhisa ^{[1
]}

机构：

[1] Osaka Med Coll, Dept Gen & Gastroenterol Surg, 2-7 Daigaku Machi, Takatsuki, Osaka 5698686, Japan

[2] Osaka Med Coll, Translat Res Program, 2-7 Daigaku Machi, Takatsuki, Osaka 5698686, Japan

来源：

SURGERY TODAY | 2020年 / 50卷 / 04期

关键词：

Pancreatic ductal adenocarcinoma; Pulmonary metastasis; Metastasectomy; ADJUVANT CHEMOTHERAPY; RESECTION; GEMCITABINE; RECURRENCE; SURVIVAL; CANCER;

D O I：

10.1007/s00595-019-01902-w

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Patients who undergo pancreatectomy for pancreatic ductal adenocarcinoma (PDA) develop relatively early recurrence, but pulmonary metastasis from PDA is rare. Between January 2008 and December 2016, a total of 120 consecutive patients underwent pancreatectomy for primary PDA at Osaka Medical College Hospital. Among these, 13 patients developed pulmonary metastasis and 6 patients underwent pulmonary metastasectomy. Among these patients, the median disease-free survival following initial pancreatic surgery was 26.1 months, and the median overall survival (OS) interval was 39 months. On the other hand, seven patients did not undergo pulmonary resection. The median OS interval of these patients was 33 months. The 1-, 3-, and 5-year OS rates were 100%, 80%, and 60%, respectively, for patients who underwent pulmonary metastasectomy and 100.0%, 42.8%, and 0%, respectively, for those who did not undergo the procedure. Our experience has shown that surgical resection may lengthen the survival time of patients who tolerate surgery.

引用

页码：413 / 418

页数：6

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