Thiolato-Bridged Arene-Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2]

被引：51
|
作者：
Ibao, Anne-Flore [1 ]
Gras, Michael [1 ]
Therrien, Bruno [1 ]
Suess-Fink, Georg [1 ]
Zava, Olivier [2 ]
Dyson, Paul J. [2 ]
机构：
[1] Univ Neuchatel, Inst Chim, CH-2000 Neuchatel, Switzerland
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2012年 / 09期
基金：
瑞士国家科学基金会;
关键词：
Ruthenium; Arene ligands; Thiolato bridges; Cytotoxicity; DIRUTHENIUM COMPLEXES; BENZENE; AGENTS;
D O I：
10.1002/ejic.201101057
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene = p-MeC6H4iPr and R = CH2Ph (1), CH2CH2Ph (2), CH2C6H4-p-tBu (3), and C6H11 (4). The single-crystal X-ray structure analysis of the p-tert-butylbenzyl derivative 3 reveals that the two ruthenium atoms are bridged by the two thiolato ligands without a metalmetal bond. The neutral dithiolato complexes[(arene)2Ru2(SR)2Cl2] (13) are intermediates in the formation of the cationic trithiolato complexes [(arene)2Ru2(SR)3]+ (57). Of the new [(arene)2Ru2(SR)2Cl2] complexes, derivative 2 is highly cytotoxic against human ovarian cancer cells, with IC50 values of 0.20 mu M for the A2780 cell line and 0.31 for the cisplatin-resistant cell line A2780cisR.
引用
收藏
页码：1531 / 1535
页数：5
相关论文
共 50 条
  • [21] Derivation of Structure-Activity Relationships from the Anticancer Properties of Ruthenium(II) Arene Complexes with 2-Aryldiazole Ligands
    Martinez-Alonso, Marta
    Busto, Natalia
    Jalon, Felix A.
    Manzano, Blanca R.
    Leal, Jose M.
    Rodriguez, Ana M.
    Garcia, Begona
    Espino, Gustavo
    INORGANIC CHEMISTRY, 2014, 53 (20) : 11274 - 11288
  • [22] Synthesis, characterization and in vitro anticancer activity of highly cytotoxic trithiolato diruthenium complexes of the type [(η6-p-MeC6H4iPr)2Ru2(μ2-SR1)2(μ2-SR2)]+ containing different thiolato bridges
    Giannini, Federico
    Furrer, Julien
    Suess-Fink, Georg
    Clavel, Catherine M.
    Dyson, Paul J.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2013, 744 : 41 - 48
  • [23] Synthesis and structural characterisation of new cationic dinuclear ruthenium(II) thiolato complexes of the type [Ru2(η6-arene)2(μ-p-S-C6H4-Br)3]+
    Chérioux, F
    Therrien, B
    Süss-Fink, G
    INORGANICA CHIMICA ACTA, 2004, 357 (03) : 834 - 838
  • [24] Synthesis and characterization of Ru(II) arene complexes, [Ru(η6-arene)(dppm)H]+ (η6-arene=benzene, p-cymene or hexamethylbenzene), [Ru(η6-arene)(py)3]2+ and [Ru(η6-arene)(py)2Cl]+
    Sisodiya, OS
    Sahay, AN
    Pandey, DS
    INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 2000, 39 (04): : 453 - 456
  • [25] Synthesis and characterization of [(η6-arene)Ru(R3P)Cl2] complexes
    Redwine, KD
    Hansen, HD
    Bowley, S
    Isbell, J
    Sanchez, M
    Vodak, D
    Nelson, JH
    SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY, 2000, 30 (03): : 379 - 407
  • [26] Arene-ruthenium complexes with 2-(arylazo)phenol as ancillary ligand: Synthesis, characterization, and utilization in catalytic transfer-hydrogenation
    Karmakar, Jit
    Bhattacharya, Samaresh
    POLYHEDRON, 2019, 172 : 39 - 44
  • [27] 1,2,3-Triazolylidene ruthenium(II)(η6-arene) complexes: synthesis, metallation and reactivity
    Bagh, Bidraha
    McKinty, Adam M.
    Lough, Alan J.
    Stephan, Douglas W.
    DALTON TRANSACTIONS, 2014, 43 (34) : 12842 - 12850
  • [28] Highly cytotoxic diruthenium trithiolato complexes of the type [(η6-p-MeC6H4Pri)2Ru2(μ2-SR)3]+: synthesis, characterization, molecular structure and in vitro anticancer activity
    Giannini, Federico
    Paul, Lydia E. H.
    Furrer, Julien
    Therrien, Bruno
    Suess-Fink, Georg
    NEW JOURNAL OF CHEMISTRY, 2013, 37 (11) : 3503 - 3511
  • [29] Syntheses and structures of two arene-ruthenium(II) complexes with cyclometalating 2-pyridyl-m-tolyl ligands
    Zhang, Xiu-Zhen
    Yao, Wen-Rui
    Zhang, Qian-Feng
    Leung, Wa-Hung
    Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, 62 (05): : 675 - 678
  • [30] Syntheses and structures of two arene-ruthenium(II) complexes with cyclometalating 2-pyridyl-m-tolyl ligands
    Zhang, Xiu-Zhen
    Yao, Wen-Rui
    Zhang, Qian-Feng
    Leung, Wa-Hung
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2007, 62 (05): : 675 - 678
12345