Thiolato-Bridged Arene-Ruthenium Complexes: Synthesis, Molecular Structure, Reactivity, and Anticancer Activity of the Dinuclear Complexes [(arene)2Ru2(SR)2Cl2]

被引：51
作者：
Ibao, Anne-Flore [1 ]
Gras, Michael [1 ]
Therrien, Bruno [1 ]
Suess-Fink, Georg [1 ]
Zava, Olivier [2 ]
Dyson, Paul J. [2 ]
机构：
[1] Univ Neuchatel, Inst Chim, CH-2000 Neuchatel, Switzerland
[2] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2012年 / 09期
基金：
瑞士国家科学基金会;
关键词：
Ruthenium; Arene ligands; Thiolato bridges; Cytotoxicity; DIRUTHENIUM COMPLEXES; BENZENE; AGENTS;
D O I：
10.1002/ejic.201101057
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Treatment of an areneruthenium dichloride dimer with thiols RSH to lead to cationic trithiolato complexes of the type [(arene)2Ru2(SR)3]+ was shown to proceed through the neutral thiolato complexes [(arene)2Ru2(SR)2Cl2], which have been isolated and characterized for arene = p-MeC6H4iPr and R = CH2Ph (1), CH2CH2Ph (2), CH2C6H4-p-tBu (3), and C6H11 (4). The single-crystal X-ray structure analysis of the p-tert-butylbenzyl derivative 3 reveals that the two ruthenium atoms are bridged by the two thiolato ligands without a metalmetal bond. The neutral dithiolato complexes[(arene)2Ru2(SR)2Cl2] (13) are intermediates in the formation of the cationic trithiolato complexes [(arene)2Ru2(SR)3]+ (57). Of the new [(arene)2Ru2(SR)2Cl2] complexes, derivative 2 is highly cytotoxic against human ovarian cancer cells, with IC50 values of 0.20 mu M for the A2780 cell line and 0.31 for the cisplatin-resistant cell line A2780cisR.
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收藏
页码：1531 / 1535
页数：5
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