Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

被引：369

作者：

Aksamitiene, Edita ^{[2
]}

Kiyatkin, Anatoly ^{[2
]}

Kholodenko, Boris N. ^{[1
,2
]}

机构：

[1] Univ Coll Dublin, Dublin 2, Ireland

[2] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2012年 / 40卷

基金：

美国国家卫生研究院; 爱尔兰科学基金会;

关键词：

Akt; cross-talk; mitogen-activated protein kinase (MAPK); phosphoinositide 3-kinase (PI3K); Ras; FACTOR-MEDIATED INTERACTION; BREAST-CANCER CELLS; PHOSPHATIDYLINOSITOL; 3-KINASE; SIGNAL-TRANSDUCTION; MAP KINASE; TYROSINE PHOSPHORYLATION; DOCKING PROTEINS; ERK ACTIVATION; C-CBL; GROWTH;

D O I：

10.1042/BST20110609

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate that cross-talk is context-dependent and that both pathways can activate or inhibit each other. Positive influence of the PI3K pathway on the MAPK pathway is most effective at sufficiently low doses of growth factors, whereas negative influence of the MAPK pathway on the PI3K pathway is mostly pronounced at high doses of growth factors. Pathway cross-talk endows a cell with emerging capabilities for processing and decoding signals from multiple receptors activated by different combinations of extracellular cues.

引用

收藏

页码：139 / 146

页数：8

相关论文

共 64 条

[1] PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells [J].

Aksamitiene, Edita ;

Kholodenko, Boris N. ;

Kolch, Walter ;

Hoek, Jan B. ;

Kiyatkin, Anatoly .

CELLULAR SIGNALLING, 2010, 22 (09) :1369-1378

[2] Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β [J].

Al-Khouri, AM ;

Ma, YL ;

Togo, SH ;

Williams, S ;

Mustelin, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (42) :35195-35202

[3] Prostaglandin F2α Represses IGF-I-Stimulated IRS1/Phosphatidylinositol-3-Kinase/AKT Signaling in the Corpus Luteum: Role of ERK and P70 Ribosomal S6 Kinase [J].

Arvisais, Edward ;

Hou, Xiaoying ;

Wyatt, Todd A. ;

Shirasuna, Koumei ;

Bollwein, Heinrich ;

Miyamoto, Akio ;

Hansen, Thomas R. ;

Rueda, Bo R. ;

Davis, John S. .

MOLECULAR ENDOCRINOLOGY, 2010, 24 (03) :632-643

[4] A human MAP kinase interactome [J].

Bandyopadhyay, Sourav ;

Chiang, Chih-yuan ;

Srivastava, Jyoti ;

Gersten, Merril ;

White, Suhaila ;

Bell, Russell ;

Kurschner, Cornelia ;

Martin, Christopher H. ;

Smoot, Mike ;

Sahasrabudhe, Sudhir ;

Barber, Diane L. ;

Chanda, Sumit K. ;

Ideker, Trey .

NATURE METHODS, 2010, 7 (10) :801-U50

[5] Systems-level interactions between insulin-EGF networks amplify mitogenic signaling [J].

Borisov, Nikolay ;

Aksamitiene, Edita ;

Kiyatkin, Anatoly ;

Legewie, Stefan ;

Berkhout, Jan ;

Maiwald, Thomas ;

Kaimachnikov, Nikolai P. ;

Timmer, Jens ;

Hoek, Jan B. ;

Kholodenko, Boris N. .

MOLECULAR SYSTEMS BIOLOGY, 2009, 5

[6] Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 [J].

Chaudhary, A ;

King, WG ;

Mattaliano, MD ;

Frost, JA ;

Diaz, B ;

Morrison, DK ;

Cobb, MH ;

Marshall, MS ;

Brugge, JS .

CURRENT BIOLOGY, 2000, 10 (09) :551-554

[7] Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts [J].

Choi, WS ;

Sung, CK .

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2004, 24 (1-2) :67-83

[8] EGF-induced Grb7 Recruits and Promotes Ras Activity Essential for the Tumorigenicity of Sk-Br3 Breast Cancer Cells [J].

Chu, Pei-Yu ;

Li, Tsai-Kun ;

Ding, Shih-Torng ;

Lai, I-Rue ;

Shen, Tang-Long .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (38) :29279-29285

[9] The renaissance of GSK3 [J].

Cohen, P ;

Frame, S .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :769-776

[10] Regulation of the mitogen-activated protein kinase signaling pathway by SHP2 [J].

Cunnick, JM ;

Meng, SS ;

Ren, Y ;

Desponts, C ;

Wang, HG ;

Djeu, JY ;

Wu, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9498-9504

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