共 43 条
Ex-vivo generation of human red cells for transfusion
被引:39
作者:

Anstee, David J.
论文数: 0 引用数: 0
h-index: 0
机构:
NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England
Sch Biochem, Bristol, Avon, England NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England

Gampel, Alexandra
论文数: 0 引用数: 0
h-index: 0
机构:
NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England
Sch Biochem, Bristol, Avon, England NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England

Toye, Ashley M.
论文数: 0 引用数: 0
h-index: 0
机构:
NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England
Sch Biochem, Bristol, Avon, England NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England
机构:
[1] NHSBT Filton, Bristol Inst Transfus Sci, Bristol, Avon, England
[2] Sch Biochem, Bristol, Avon, England
基金:
英国惠康基金;
关键词:
haematopoietic stem cells;
red blood cells;
reticulocytes;
scaffolds;
transfusion;
BONE-MARROW-CELLS;
CORD BLOOD;
IN-VITRO;
CD34(+) CELLS;
EXPANSION;
MANUFACTURE;
SCAFFOLDS;
CULTURE;
YIELD;
D O I:
10.1097/MOH.0b013e328352240a
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Purpose of review The present article reviews the recent data concerning the generation of red blood cells from haematopoietic stem cells using laboratory culture and discusses the potential for generating cultured red cells in sufficient quantity for use in transfusion practice. Recent findings Functional human reticulocytes have been generated from adult peripheral blood haematopoietic stem cells in laboratory culture without the use of heterologous feeder cells and their viability was demonstrated in vivo. Human erythroid progenitor cells lines have been produced from cord and human induced pluripotent stem cell (hiPSC) haematopoietic progenitors. Summary Availability of cultured human red cells from haematopoietic stem cells in the quantities required for transfusion therapy would have a major impact on healthcare provision worldwide. Recent studies provide cause for optimism that this ambitious goal is achievable. Functional adult reticulocytes have been made in culture and shown to survive in vivo. Erythroid progenitor cell lines have been derived from cord blood and from human induced pluripotent stem cells, suggesting that large-scale culture of erythroid cell lines and their differentiation to reticulocytes will be possible. Significant problems remain. More efficient enucleation and induction of maturation to an adult phenotype will be required in order to exploit high proliferative capacity of human embryonic stem cells and hiPSCs. Novel bioengineering solutions will be required to generate cultured red cells in the large quantities required, and in this context, use of synthetic three-dimensional scaffolds to mimic the bone marrow niche holds great promise for the future.
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页码:163 / 169
页数:7
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共 43 条
- [1] Production of erythroid cells from human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPS)[J]. TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2010, 17 (03) : 104 - 109Anstee, D. J.论文数: 0 引用数: 0 h-index: 0机构: NHSBT, Bristol Inst Transfus Sci, Bristol BS34 7QG, Avon, England NHSBT, Bristol Inst Transfus Sci, Bristol BS34 7QG, Avon, England
- [2] Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells[J]. SCIENCE, 2010, 329 (5997) : 1345 - 1348Boitano, Anthony E.论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USAWang, Jian论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USARomeo, Russell论文数: 0 引用数: 0 h-index: 0机构: Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USABouchez, Laure C.论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USAParker, Albert E.论文数: 0 引用数: 0 h-index: 0机构: Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USASutton, Sue E.论文数: 0 引用数: 0 h-index: 0机构: Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USAWalker, John R.论文数: 0 引用数: 0 h-index: 0机构: Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USAFlaveny, Colin A.论文数: 0 引用数: 0 h-index: 0机构: Penn State Univ, University Pk, PA 16803 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USAPerdew, Gary H.论文数: 0 引用数: 0 h-index: 0机构: Penn State Univ, University Pk, PA 16803 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USADenison, Michael S.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Davis, Davis, CA 95616 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USASchultz, Peter G.论文数: 0 引用数: 0 h-index: 0机构: Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USACooke, Michael P.论文数: 0 引用数: 0 h-index: 0机构: Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
- [3] Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts[J]. STEM CELLS, 2005, 23 (08) : 1066 - 1072Braccini, A论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandWendt, D论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandJaquiery, C论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandJakob, M论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandHeberer, M论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandKenins, L论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandWodnar-Filipowicz, A论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandQuarto, R论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, SwitzerlandMartin, I论文数: 0 引用数: 0 h-index: 0机构: Univ Basel Hosp, Inst Surg Res & Hosp Management, Dept Surg, CH-4031 Basel, Switzerland
- [4] Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview[J]. STEM CELLS INTERNATIONAL, 2011, 2011Chang, Kai-Hsin论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USABonig, Halvard论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA Goethe Univ Frankfurt, Dept Cellular Therapeut Cell Proc, Inst Transfus Med & Immunohematol, German Red Cross Blood Serv, D-60528 Frankfurt, Germany Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USAPapayannopoulou, Thalia论文数: 0 引用数: 0 h-index: 0机构: Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA
- [5] Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells[J]. EXPERIMENTAL HEMATOLOGY, 2007, 35 (05) : 771 - 781Chua, Kian-Ngiap论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, SingaporeChai, Chou论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, SingaporeLee, Peng-Chou论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, SingaporeRamakrishna, Seeram论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, SingaporeLeong, Kam W.论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, SingaporeMao, Hai-Quan论文数: 0 引用数: 0 h-index: 0机构: Natl Univ Singapore, Div Bioengn, Singapore 117548, Singapore
- [6] A Robust Ex Vivo culture System for Production of Mature Human Reticulocytes From a Single Donor[J]. BLOOD, 2011, 118 (21) : 918 - 918Cogan, Nicola论文数: 0 引用数: 0 h-index: 0机构: NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, England NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, EnglandKupzig, Sabine论文数: 0 引用数: 0 h-index: 0机构: NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, England NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, EnglandParsons, Steve F.论文数: 0 引用数: 0 h-index: 0机构: NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, England NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, EnglandAnstee, David J.论文数: 0 引用数: 0 h-index: 0机构: Univ Bristol, Bristol, Avon, England NHSBT, Bristol Inst Transfus Sci, Bristol, Avon, England
- [7] Generation of Red Blood Cells from Human Induced Pluripotent Stem Cells[J]. STEM CELLS AND DEVELOPMENT, 2011, 20 (09) : 1639 - 1647Dias, Jessica论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USAGumenyuk, Marina论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USAKang, HyunJun论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Grad Sch, Natl Primate Res Ctr, Madison, WI 53715 USA Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USAVodyanik, Maxim论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Grad Sch, Natl Primate Res Ctr, Madison, WI 53715 USA Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USAYu, Junying论文数: 0 引用数: 0 h-index: 0机构: Morgridge Inst Res, Madison, WI USA Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USAThomson, James A.论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Grad Sch, Natl Primate Res Ctr, Madison, WI 53715 USA Morgridge Inst Res, Madison, WI USA Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USASlukvin, Igor I.论文数: 0 引用数: 0 h-index: 0机构: Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USA Univ Wisconsin, Grad Sch, Natl Primate Res Ctr, Madison, WI 53715 USA Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI 53715 USA
- [8] Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 78A (04) : 781 - 791Feng, Qi论文数: 0 引用数: 0 h-index: 0机构: Div Biomed Sci, Singapore 138669, SingaporeChai, Chou论文数: 0 引用数: 0 h-index: 0机构: Div Biomed Sci, Singapore 138669, SingaporeJiang, Xue-Song论文数: 0 引用数: 0 h-index: 0机构: Div Biomed Sci, Singapore 138669, SingaporeLeong, Kam W.论文数: 0 引用数: 0 h-index: 0机构: Div Biomed Sci, Singapore 138669, SingaporeMao, Hai-Quan论文数: 0 引用数: 0 h-index: 0机构: Div Biomed Sci, Singapore 138669, Singapore
- [9] Ex vivo large-scale generation of human red blood cells from cord blood CD34+ cells by co-culturing with macrophages[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY, 2008, 87 (04) : 339 - 350Fujimi, Akihito论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanMatsunaga, Takuya论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanKobune, Masayoshi论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanKawano, Yutaka论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanNagaya, Taiko论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanTanaka, Ikuta论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanIyama, Satoshi论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanHayashi, Tsuyoshi论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanSato, Tsutomu论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanMiyanishi, Koji论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanSagawa, Tamotsu论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanSato, Yasushi论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanTakimoto, Rishu论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanTakayama, Tetsuji论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanKato, Junji论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanGasa, Shinsei论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Dept Chem, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanSakai, Hiromi论文数: 0 引用数: 0 h-index: 0机构: Waseda Univ, Adv Res Inst Sci & Engn, Tokyo, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanTsuchida, Eishun论文数: 0 引用数: 0 h-index: 0机构: Waseda Univ, Adv Res Inst Sci & Engn, Tokyo, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanIkebuchi, Kenji论文数: 0 引用数: 0 h-index: 0机构: Saitama Med Sch Hosp, Dept Transfus & Cell Therapy, Saitama, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanHamada, Hirofumi论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Dept Mol Med, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, JapanNiitsu, Yoshiro论文数: 0 引用数: 0 h-index: 0机构: Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan Sapporo Med Univ, Sch Med, Dept Internal Med 4, Chuo Ku, Sapporo, Hokkaido, Japan
- [10] ENDOCYTOSIS AND EXOCYTOSIS IN MEMBRANE REMODELING DURING RETICULOCYTE MATURATION[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1974, 28 (04) : 463 - +GASKO, O论文数: 0 引用数: 0 h-index: 0机构: WEIZMANN INST SCI, SECT BIOL ULTRASTRUCT, REHOVOTH, ISRAEL WEIZMANN INST SCI, SECT BIOL ULTRASTRUCT, REHOVOTH, ISRAELDANON, D论文数: 0 引用数: 0 h-index: 0机构: WEIZMANN INST SCI, SECT BIOL ULTRASTRUCT, REHOVOTH, ISRAEL WEIZMANN INST SCI, SECT BIOL ULTRASTRUCT, REHOVOTH, ISRAEL