Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. The molecular basis of scar formation

被引：169
作者：
Profyris, Christos [2 ]
Tziotzios, Christos [1 ]
Do Vale, Isabel [3 ]
机构：
[1] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Cambridge CB2 0QQ, England
[2] Chelsea & Westminster Hosp, Dept Plast & Burns, London, England
[3] Charlotte Maxeke Johannesburg Acad Hosp, Dept Plast & Reconstruct Surg, Parktown, South Africa
来源：
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2012年 / 66卷 / 01期
关键词：
cutaneous scar; early growth response protein-1; homeobox13; interleukins; mechanisms of scarring; platelet-derived growth factor; transforming growth factor-beta; Wnt pathway; GROWTH-FACTOR-BETA; FETAL WOUND REPAIR; TRANSFORMING GROWTH-FACTOR-BETA-1; HYPERTROPHIC SCARS; RAPID INDUCTION; TISSUE-REPAIR; HUMAN SKIN; TGF-BETA; EXPRESSION; MOUSE;
D O I：
10.1016/j.jaad.2011.05.055
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
引用
收藏
页码：1 / 10
页数：10
相关论文
共 37 条
  • [21] Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair
    Liechty, KW
    Adzick, NS
    Crombleholme, TM
    [J]. CYTOKINE, 2000, 12 (06) : 671 - 676
  • [22] Hoxb13 knockout adult skin exhibits high levels of hyaluronan and enhanced wound healing
    Mack, JA
    Abramson, SR
    Ben, YX
    Coffin, JC
    Rothrock, JK
    Maytin, EV
    Hascall, VC
    Largman, C
    Stelnicki, EJ
    [J]. FASEB JOURNAL, 2003, 17 (08) : 1352 - +
  • [23] Wound healing in the PU.1 null mouse - Tissue repair is not dependent on inflammatory cells
    Martin, P
    D'Souza, D
    Martin, J
    Grose, R
    Cooper, L
    Maki, R
    McKercher, SR
    [J]. CURRENT BIOLOGY, 2003, 13 (13) : 1122 - 1128
  • [24] RAPID INDUCTION AND CLEARANCE OF TGF-BETA-1 IS AN EARLY RESPONSE TO WOUNDING IN THE MOUSE EMBRYO
    MARTIN, P
    DICKSON, MC
    MILLAN, FA
    AKHURST, RJ
    [J]. DEVELOPMENTAL GENETICS, 1993, 14 (03): : 225 - 238
  • [25] McGregor AD, 2000, WOUND MANAGEMENT FUN, P3
  • [26] Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
    Mori, Ryoichi
    Shaw, Tanya J.
    Martin, Paul
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (01) : 43 - 51
  • [27] Keratinocyte-derived growth factors play a role in the formation of hypertrophic scars
    Niessen, FB
    Andriessen, MP
    Schalkwijk, J
    Visser, L
    Timens, W
    [J]. JOURNAL OF PATHOLOGY, 2001, 194 (02) : 207 - 216
  • [28] TRANSFORMING GROWTH-FACTOR TYPE-BETA - RAPID INDUCTION OF FIBROSIS AND ANGIOGENESIS INVIVO AND STIMULATION OF COLLAGEN FORMATION INVITRO
    ROBERTS, AB
    SPORN, MB
    ASSOIAN, RK
    SMITH, JM
    ROCHE, NS
    WAKEFIELD, LM
    HEINE, UI
    LIOTTA, LA
    FALANGA, V
    KEHRL, JH
    FAUCI, AS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (12) : 4167 - 4171
  • [29] Upregulation of the Wnt/β-catenin pathway induced by transforming growth factor-β in hypertrophic scars and keloids
    Sato, Madoka
    [J]. ACTA DERMATO-VENEREOLOGICA, 2006, 86 (04) : 300 - 307
  • [30] Transcriptional control of wound repair
    Schaefer, Matthias
    Werner, Sabine
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2007, 23 : 69 - 92
1234