Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model

被引：28

作者：

Cecconi, Alberto ^{[1
,2
]}

Paul Vilchez-Tschischke, Jean ^{[1
,3
]}

Mateo, Jesus ^{[1
]}

Sanchez-Gonzalez, Javier ^{[4
]}

Espana, Samuel ^{[1
]}

Fernandez-Jimenez, Rodrigo ^{[1
,5
,6
]}

Lopez-Melgar, Beatriz ^{[1
,6
,7
]}

Fernandez Friera, Leticia ^{[1
,6
,8
]}

Lopez-Martin, Gonzalo J. ^{[1
]}

Fuster, Valentin ^{[1
,5
]}

Ruiz-Cabello, Jesus ^{[9
,10
,11
,12
]}

Ibanez, Borja ^{[1
,6
,13
]}

机构：

[1] Ctr Nacl Invest Cardiovasc CNIC, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain

[2] Hosp Univ La Princesa, Serv Cardiol, Madrid, Spain

[3] Complejo Hosp Ruber Juan Bravo, Serv Cardiol, Madrid, Spain

[4] Philips Healthcare, Madrid, Spain

[5] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[6] CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain

[7] Hosp Univ HM Puerta Sur, Serv Cardiol, Mostoles, Spain

[8] HM Hosp Ctr Integral Enfermedades Cardiovasc HM C, Madrid, Spain

[9] CIC BiomaGUNE, Donostia San Sebastian 20014, Spain

[10] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

[11] CIBER Enfermedades Resp CIBERES, Madrid, Spain

[12] Univ Complutense Madrid, Madrid, Spain

[13] IIS Fdn Jimenez Diaz Hosp, Serv Cardiol, Madrid, Spain

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2021年 / 14卷 / 01期

关键词：

Imaging; Atherosclerosis; Animal model; Colchicine; Inflammation; Plaque morphology; FLUORODEOXYGLUCOSE UPTAKE; VASCULAR INFLAMMATION; VULNERABLE PLAQUE; CORONARY; NEUTROPHIL; DISEASE; LESIONS; TOMOGRAPHY; PREVALENCE; PREVENTION;

D O I：

10.1007/s12265-020-09974-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI,F-18-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum(18)F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.

引用

页码：150 / 160

页数：11

共 51 条

[1] Colchicine Pharmacokinetics and Mechanism of Action [J].

Angelidis, Christos ;

Kotsialou, Zoi ;

Kossyvakis, Charalampos ;

Vrettou, Agathi-Rosa ;

Zacharoulis, Achilleas ;

Kolokathis, Fotios ;

Kekeris, Vasilios ;

Giannopoulos, Georgios .

CURRENT PHARMACEUTICAL DESIGN, 2018, 24 (06) :659-663

[2] The Myth of the "Vulnerable Plaque" Transitioning From a Focus on Individual Lesions to Atherosclerotic Disease Burden for Coronary Artery Disease Risk Assessment [J].

Arbab-Zadeh, Armin ;

Fuster, Valentin .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (08) :846-855

[3]

BAURIEDEL G, 1994, CORONARY ARTERY DIS, V5, P531

[4] Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin [J].

Bhattacharyya, Bhabatarak ;

Panda, Dulal ;

Gupta, Suvroma ;

Banerjee, Mithu .

MEDICINAL RESEARCH REVIEWS, 2008, 28 (01) :155-183

[5] CRYSTAL-INDUCED INFLAMMATION IN THE RAT SUBCUTANEOUS AIR-POUCH [J].

BROOKS, PM ;

BURTON, D ;

FORREST, MJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 90 (02) :413-419

[6] Fast plaque burden assessment of the femoral artery using 3D black-blood MRI and automated segmentation [J].

Chiu, Bernard ;

Sun, Jie ;

Zhao, Xihai ;

Wang, Jinnan ;

Balu, Niranjan ;

Chi, Jiachang ;

Xu, Jianrong ;

Yuan, Chun ;

Kerwin, William S. .

MEDICAL PHYSICS, 2011, 38 (10) :5370-5384

[7] Colchicine reduces platelet aggregation by modulating cytoskeleton rearrangement via inhibition of cofilin and LIM domain kinase 1 [J].

Cimmino, Giovanni ;

Tarallo, Roberta ;

Conte, Stefano ;

Morello, Andrea ;

Pellegrino, Grazia ;

Loffredo, Francesco S. ;

Cali, Gaetano ;

De Luca, Nicola ;

Golino, Paolo ;

Trimarco, Bruno ;

Cirillo, Plinio .

VASCULAR PHARMACOLOGY, 2018, 111 :62-70

[8] Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout [J].

Crittenden, Daria B. ;

Lehmann, R. Aaron ;

Schneck, Laura ;

Keenan, Robert T. ;

Shah, Binita ;

Greenberg, Jeffrey D. ;

Cronstein, Bruce N. ;

Sedlis, Steven P. ;

Pillinger, Michael H. .

JOURNAL OF RHEUMATOLOGY, 2012, 39 (07) :1458-1464

[9] Colchicine Treatment for the Prevention of Bare-Metal Stent Restenosis in Diabetic Patients [J].

Deftereos, Spyridon ;

Giannopoulos, Georgios ;

Raisakis, Konstantinos ;

Kossyvakis, Charalambos ;

Kaoukis, Andreas ;

Panagopoulou, Vasiliki ;

Driva, Metaxia ;

Hahalis, George ;

Pyrgakis, Vlasios ;

Alexopoulos, Dimitrios ;

Manolis, Antonis S. ;

Stefanadis, Christodoulos ;

Cleman, Michael W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (16) :1679-1685

[10] Microtubule Dynamics Control Tail Retraction in Migrating Vascular Endothelial Cells [J].

Ganguly, Anutosh ;

Yang, Hailing ;

Zhang, Hong ;

Cabral, Fernando ;

Patel, Kamala D. .

MOLECULAR CANCER THERAPEUTICS, 2013, 12 (12) :2837-2846

← 1 2 3 4 5 6 →