Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools

被引：10

作者：

Wiedmer, Tabea ^{[1
]}

Ingles-Prieto, Alvaro ^{[1
]}

Goldmann, Ulrich ^{[1
]}

Steppan, Claire M. ^{[2
]}

Superti-Furga, Giulio ^{[1
,3
]}

机构：

[1] Austrian Acad Sci, CeMM Res Ctr Mol Med, Vienna, Austria

[2] Pfizer Worldwide Res, Dev Med, Groton, CT USA

[3] Med Univ Vienna, Ctr Physiol & Pharmacol, Vienna, Austria

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2022年 / 112卷 / 03期

基金：

欧盟地平线“2020”;

关键词：

D O I：

10.1002/cpt.2639

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A modern, rational approach to a large class of proteins broadly relevant for pharmacology is enabling both from a postgenomic perspective and for reasons of economy of scale. The international public-private consortia RESOLUTE (https://re-solute.eu/) and REsolution (https://re-solute.eu/resolution) are generating a systematic functional assignment of each of the 451 different human solute carrier (SLC) proteins and, at the same time, trying to catalog and interpret the associated main genetic variants.

引用

页码：439 / 442

页数：4

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