Morphine consumption during pregnancy exacerbates neonatal hypoxia-ischemia injury in rats

被引：12

作者：

Bornavard, Morad ^{[1
]}

Fanaei, Hamed ^{[2
]}

Mirshekar, Mohammad Ali ^{[3
]}

Mashhadi, Farzaneh Farajian ^{[4
]}

Atashpanjeh, Alireza ^{[5
]}

机构：

[1] Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran

[2] Zahedan Univ Med Sci, Pregnancy Hlth Res Ctr, Zahedan 00981687556, Iran

[3] Zahedan Univ Med Sci, Clin Immunol Res Ctr, Sch Med, Dept Physiol, Zahedan, Iran

[4] Zahedan Univ Med Sci, Cellular & Mol Res Ctr, Sch Med, Dept Pharmacol, Zahedan, Iran

[5] Zahedan Univ Med Sci, Sch Med, Dept English Language, Zahedan, Iran

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2020年 / 80卷 / 02期

关键词：

BDNF; hypoxia-ischemia; inflammation; morphine; oxidative stress; pregnancy; FOCAL CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; BRAIN-INJURY; BDNF; INHIBITOR; EXPOSURE; NEUROTOXICITY; PROTECTION; JUVENILE; DAMAGE;

D O I：

10.1002/jdn.10008

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

ObjectiveHypoxia-Ischemia (HI) is the most common cause of death and disability in human infants. The use of opiate in pregnant women affects their children. The aim of this study was to evaluate the effect of morphine consumption during pregnancy and lactation on vulnerability to neonatal HI in rats. Materials and methodsFemale Wistar rats were randomly assigned into two groups: Group 1-Rats that did not receive any treatment during pregnancy and lactation and Group 2-Rats that received morphine during pregnancy and lactation. After delivery, male offspring were divided into four groups including: (a) SHAM, (b) SHAM/Morphine (SHAM/MO), (c) HI, (d) HI/Morphine (HI/MO). Seven days after HI induction, neurobehavioral tests were performed, and then, brain tissue was taken from the skull to measure cerebral edema, infarct volume, inflammatory factors, oxidative stress, and brain-derived neurotrophic factor (BDNF). ResultsTotal antioxidant capacity (TAC) and BDNF levels in the HI/MO group were significantly lower than HI and SHAM groups. TNF-alpha, C-reactive protein and total oxidant capacity levels in the HI/MO group were significantly higher than HI and SHAM groups. Cerebral edema and infarct volume in the HI/MO group were significantly higher than the HI group. ConclusionBased on the results, morphine consumption during pregnancy and lactation enhanced the deleterious effects of HI injury in pups.

引用

页码：96 / 105

页数：10

共 58 条

[1] Deleterious effects of prenatal exposure to morphine on the spatial learning and hippocampal BDNF and long-term potentiation in juvenile rats: Beneficial influences of postnatal treadmill exercise and enriched environment [J].