Modular design of optically controlled protein affinity reagents

被引：13

作者：

Babalhavaeji, A. ^{[1
]}

Woolley, G. A. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 13期

关键词：

BINDING-PROTEINS; IN-VIVO; INHIBITORS; LIGHT; PHOTOPHARMACOLOGY; CHYMASE; THERAPEUTICS; ANTIBODIES; SCAFFOLDS; DARPINS;

D O I：

10.1039/c7cc07391g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photopharmaceuticals can, in principle, be created by linking photoswitchable moieties to bioactive molecules. However, a general strategy for converting a therapeutic agent into its photoswitchable version is not currently available. Herein we propose a generalizable, modular approach for obtaining light controllable bioactive agents by modifying the scaffold of a protein affinity reagent using an azobenzene photoswitch.

引用

页码：1591 / 1594

页数：4

共 40 条

[1] A Photoswitchable Dualsteric Ligand Controlling Receptor Efficacy [J].

Agnetta, Luca ;

Kauk, Michael ;

Canizal, Maria Consuelo Alonso ;

Messerer, Regina ;

Holzgrabe, Ulrike ;

Hoffmann, Carsten ;

Decker, Michael .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (25) :7282-7287

[2] Beyond Peptides and mAbs-Current Status and Future Perspectives for Biotherapeutics With Novel Constructs [J].

AlDeghaither, Dalal ;

Smaglo, Brandon G. ;

Weiner, Louis M. .

JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 55 (03) :S4-S20

[3] Recent advances in the development of novel protein scaffolds based therapeutics [J].

Azhar, Asim ;

Ahmad, Ejaj ;

Zia, Qamar ;

Rauf, Mohd. Ahmar ;

Owais, Mohammad ;

Ashraf, Ghulam Md .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 102 :630-641

[4] Quantitative Analysis of the Effects of Photoswitchable Distance Constraints on the Structure of a Globular Protein [J].

Beharry, Andrew A. ;

Chen, Tao ;

Al-Abdul-Wahid, M. Sameer ;

Samanta, Subhas ;

Davidov, Kirill ;

Sadovski, Oleg ;

Ali, Ahmed M. ;

Chen, Simon B. ;

Prosser, R. Scott ;

Chan, Hue Sun ;

Woolley, G. Andrew .

BIOCHEMISTRY, 2012, 51 (32) :6421-6431

[5] Azobenzene Photoswitching without Ultraviolet Light [J].

Beharry, Andrew A. ;

Sadovski, Oleg ;

Woolley, G. Andrew .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (49) :19684-19687

[6] Fluorescence Imaging of Azobenzene Photoswitching In Vivo [J].

Beharry, Andrew A. ;

Wong, Loksum ;

Tropepe, Vince ;

Woolley, G. Andrew .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (06) :1325-1327

[7] A Bispecific HER2-Targeting FynomAb with Superior Antitumor Activity and Novel Mode of Action [J].

Brack, Simon ;

Attinger-Toller, Isabella ;

Schade, Babette ;

Mourlane, Frederic ;

Klupsch, Kristina ;

Woods, Richard ;

Hachemi, Helen ;

von der Bey, Ulrike ;

Koenig-Friedrich, Susann ;

Bertschinger, Julian ;

Grabulovski, Dragan .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (08) :2030-2039

[8] The making of bispecific antibodies [J].

Brinkmann, Ulrich ;

Kontermann, Roland E. .

MABS, 2017, 9 (02) :182-212

[9] A Roadmap to Success in Photopharmacology [J].

Broichhagen, Johannes ;

Frank, James Allen ;

Trauner, Dirk .

ACCOUNTS OF CHEMICAL RESEARCH, 2015, 48 (07) :1947-1960

[10] Potent antibody therapeutics by design [J].

Carter, PJ .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (05) :343-357

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