Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity

被引：7

作者：

Du, Ning-Ning ^{[1
,2
]}

Bai, Ming ^{[1
,2
]}

Zhang, Xin ^{[1
,2
]}

Zhou, Le ^{[1
,2
]}

Huang, Xiao-Xiao ^{[1
,2
]}

Song, Shao-Jiang ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Based Nat Antitumor Drug Re, Engn Res Ctr Nat Med Act Mol Res & Dev, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Nat Bioact Cpds Discovery & Modificat, Shenyang 110016, Liaoning, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 10期

关键词：

coumarins; Sarcandra glabra; acetylcholinesterase; DIHYDROBENZOFURAN NEOLIGNANS; ENANTIOMERS; RESOLUTION; LEAVES; L;

D O I：

10.1002/cbdv.202200558

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine coumarins including a pair of new enantiomers (1a/1b) and seven known compounds (2-8) were isolated from Sarcandra glabra (Thunb.) Nakai. Among them, compounds 1a and 1b were naturally occurring coumarin-phenylpropanoid conjugate enantiomers. Their structures were identified by NMR and ECD calculations. Compounds 1-8 were tested for acetylcholinesterase (AchE) inhibiting activity. The results of the enzymology experiment showed that compound 3 demonstrated obvious AchE inhibitory activity which showed the IC50 value of 1.982 +/- 0.003 mu M, and the binding sites were predicted by molecular docking.

引用

页数：8

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