Vitamin A-Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis

被引：18
作者：
Zile, Maija H. [1 ]
机构：
[1] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA
来源：
NUTRIENTS | 2010年 / 2卷 / 05期
关键词：
vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis; RETINOIC ACID SYNTHESIS; EARLY AVIAN DEVELOPMENT; PROGRAMMED CELL-DEATH; CARDIAC NEURAL CREST; GROWTH-FACTOR BETA-2; N-CADHERIN; TGF-BETA; ENDOGENOUS RETINOIDS; ACTIVATED RECEPTOR; ADHESION RECEPTORS;
D O I：
10.3390/nu2050532
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality.
引用
收藏
页码：532 / 550
页数：19
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