Efficient synthesis of pyrrolo[2,3-d]pyrimidines via a Cu(I)/6-methylpicolinic acid catalyzed coupling reaction

被引：9

作者：

Jiang, Xi ^{[1
]}

Sun, Dequn ^{[1
]}

Jiang, Yongwen ^{[2
]}

Ma, Dawei ^{[2
]}

机构：

[1] Shangdong Univ Weihai, Marine Coll, Weihai 264209, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Coupling reaction; Heterocycle; Catalysis; Pyrrolo[2,3-d]pyrimidines; Cyclization; INHIBITORS; ARYL; DERIVATIVES; IODIDES; HALIDES;

D O I：

10.1016/j.tetlet.2014.12.098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper/6-methylpicolinic acid catalyzed coupling reaction of substituted 5-bromopyrimidin-4-amines with alkynes and subsequent cyclization took place in DMSO at 100-110 degrees C to afford 2-chloro-pyrrolo [2,3-d]pyrimidines in moderate to excellent yields. Variable functional groups, including aromatic and aliphatic groups, could be introduced at the 6 and 7 positions using this method. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3259 / 3261

页数：3

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