Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues

被引：287

作者：

Kim, YB

Kim, YH ^{[1
]}

Park, JY

Kim, SK

机构：

[1] Korea Adv Inst Sci & Technol, Ctr Mol Design & Synth, Dept Chem, Taejon 305701, South Korea

[2] Yonsei Univ, Dept Microbiol, Wonju Coll Med, Inst Basic Med Sci,IFBB, Wonju 220701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

echinomycin; anticancer; active-VRE; apoptosis;

D O I：

10.1016/j.bmcl.2003.09.086

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound la shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 mug/mL. According to the eukaryotic or prokaryotic data, la might be a first analogue to replace echinomycin. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：541 / 544

页数：4

共 33 条

[1] Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis [J].