Platelets as a 'natural factory' for growth factor production that sustains normal (and pathological) cell biology

被引:8
作者
Andrade, Sheila Siqueira [1 ]
de Sousa Faria, Alessandra Valeria [2 ]
Queluz, Dagmar de Paulo [3 ]
Ferreira-Halder, Carmen Verissima [2 ]
机构
[1] PlateInnove Biotechnol, Ave Limeira 1131, BR-13414018 Piracicaba, SP, Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP, Brazil
[3] Univ Estadual Campinas, Piracicaba Dent Sch, Ave Limeira 901, BR-13414903 Piracicaba, SP, Brazil
基金
巴西圣保罗研究基金会;
关键词
growth factors; Ingrowth; PDGF; Platelnnove; platelets; SYNTHESIZE;
D O I
10.1515/hsz-2019-0342
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Platelets have attracted substantial attention in the current decade owing to their unexpected pleiotropic properties and conflicted functions. In fact, platelets participate in both health (hemostasis) and disease (thrombotic diseases). Much of the plasticity of platelets comes from the fact that platelets are the reservoir and the 'natural factory' of growth factors (GFs), with pivotal functions in wound repair and tissue regeneration. By combining the platelets' plasticity and biotechnological processes, Platelnnove Biotechnology optimized the production of GFs in nanoparticle biointerfacing by platelet content, which opens an avenue of possibilities.
引用
收藏
页码:471 / 476
页数:6
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