Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-κ paraprotein

被引：25
作者：
Evans, DJ
Macanovic, M
Dunn, MJ
Pusey, CD
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Renal Sect,Div Med, London W12 0NN, England
[2] MRC Ctr, Mol Immunopathol Unit, Cambridge, England
[3] Inst Psychiat, Dept Neurosci, London SE5 8AF, England
来源：
NEPHRON CLINICAL PRACTICE | 2003年 / 93卷 / 03期
关键词：
membranous glomerulonephritis; lymphoma; chronic lymphocytic leukaemia; paraprotein; immune deposits;
D O I：
10.1159/000069548
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A case is described of B-cell lymphoma/chronic lymphocytic leukaemia associated with membranous glomerulonephritis in which the subepithelial deposits of immunoglobulin showed I light chain restriction by immunofluorescence. Surface IgG-kappa immunoglobulin was demonstrated on the malignant B cells, and a monoclonal protein of the same type was eluted from kidney. The mechanism of membranous glomerulonephritis in this type of lymphoid malignancy is clearly different from that in epithelial malignancies. Copyright (C) 2003 S. Karger AG, Basel.
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收藏
页码：C112 / C118
页数：7
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