Palladium-Catalyzed Tandem Cyclization of 2-(2 Ethynylphenyl)acetonitriles and Isocyanides: Access to Indeno[2,1-b]pyrroles

被引：10
作者：
Lin, Hui-Shu [1 ]
Pan, Yong-Zhou [2 ]
Tian, Yu-Hong [1 ]
Pan, Ying-Ming [2 ]
Wang, Xu [1 ,2 ]
机构：
[1] Guangxi Univ Sci & Technol, Coll Biol & Chem Engn, Guangxi Key Lab Green Proc Sugar Resources, Liuzhou 545006, Peoples R China
[2] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 06期
基金：
中国博士后科学基金;
关键词：
Palladium-catalyed; Tandem cyclisation reaction; Isocyanide insertion; Indeno[2,1-b]pyrroles; PROTEIN-KINASE CK2; ARYL HALIDES; INSERTION; BINDING; FUNCTIONALIZATION; INHIBITOR; CK2-ALPHA; DIVERSE; OXIMES; POTENT;
D O I：
10.1002/adsc.202101311
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A palladium-catalyzed tandem cyclization of 2-(2-ethynylphenyl)acetonitriles with isocyanides has been developed. Various indeno[2,1-b]pyrroles were prepared in 55%-82% yields under air atmosphere at 100 degrees C. The key to the success of this protocol is construction of new C-C and C-N bonds via the orderly insertion of isocyanides.
引用
收藏
页码：1117 / 1121
页数：5
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