Benzyltrifluoromethyl (or Fluoroalkyl) Selenide: Reagent for Electrophilic Trifluoromethyl (or Fluoroalkyl) Selenolation

被引：85
作者：
Glenadel, Quentin [1 ]
Ismalaj, Ermal [1 ]
Billard, Thierry [1 ]
机构：
[1] Univ Lyon 1, Inst Chem & Biochem ICBMS UMR CNRS 5246, CNRS, 43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 18期
关键词：
FLUORINE; SELENOETHERS; DISULFIDES; KETONES; ARYL; TRIMETHYLSILANE; ALDEHYDES; SULFIDES; IMINES; ACCESS;
D O I：
10.1021/acs.joc.6b01344
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Trifluoromethylseleno substituent (CF3Se) is an emerging group, but its direct introduction onto organic molecules is still quite limited and mainly restricted to nucleophilic methods. Herein, we describe a new approach to easily and safely perform electrophilic trifluorome-thylselenolation starting from a simple and easily accessible reagent, namely, benzyltrifluoromethyl selenide. This strategy can be generalized to various fluoroalkylselanyl groups, even functionalized ones.
引用
收藏
页码：8268 / 8275
页数：8
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