The Self-Assembly of Diblock Copolymers MePEG-b-PAAm into Micellar Structures and Their Interaction with Doxorubicin

被引：9
作者：
Kunitskaya, L. R. [1 ]
Zheltonozhskaya, T. B. [1 ]
Aleinichenko, V. A. [1 ]
Roshal, A. D. [2 ]
Khayetsky, I. K. [3 ]
机构：
[1] Taras Shevchenko Natl Univ Kyiv, Fac Chem, UA-01033 Kiev, Ukraine
[2] Kharkov Natl Univ, Inst Chem, Kharkov, Ukraine
[3] RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, Kiev, Ukraine
来源：
MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2011年 / 536卷
关键词：
Acrylamide; block copolymers; doxorubicin; micellization; polyethylene glycol; POLY(ETHYLENE OXIDE); BLOCK-COPOLYMERS; MODELS;
D O I：
10.1080/15421406.2011.538603
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The micellization of asymmetric diblock copolymers (DBC) MePEG-b-PAAm formed by monomethoxy-poly(ethylene)oxide (MePEG) and polyacrylamide (PAAm) has been studied in water, a water/alcohol mixture, and a NaCl solution. The effect of added NaCl on the critical micellization concentration of DBC water solutions was examined. The interaction between DBC and antitumor drug doxorubicin is discussed. The analysis of the UV spectrum of doxorubicin is performed.
引用
收藏
页码：166 / 172
页数：7
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