Synthesis of Functionalized Quinolines through a Reaction of Amides and Alkynes Promoted by Triflic Anhydride/Pyridine

被引：34
作者：
Li, Lian-Hua [1 ]
Niu, Zhi-Jie [1 ]
Liang, Yong-Min [1 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 61期
基金：
中国国家自然科学基金;
关键词：
metal-free; quinoline; regioselectivity; synthesis; triflic anhydride; C-H ACTIVATION; SECONDARY AMIDES; ELECTROPHILIC ACTIVATION; CHEMOSELECTIVE SYNTHESIS; DIRECT TRANSFORMATION; TANDEM REACTION; BOND-CLEAVAGE; ACCESS; COPPER; KETONES;
D O I：
10.1002/chem.201703832
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise, novel and flexible metal-free single step to synthesize functionalized quinolines is reported. Triflic anhydride-mediated (Tf2O) activation of amides is discussed in the presence of pyridine to offer strong electrophiles, thereby showcasing excellent productivity, high regio- and chemoselectivity, and widely tolerable substrates. This approach provides a straightforward and efficient way to construct azaheterocycle structures.
引用
收藏
页码：15300 / 15304
页数：5
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