A Prospective Cohort Study of Bioavailable 25-Hydroxyvitamin D Levels as a Marker of Vitamin D Status in Nontuberculous Mycobacterial Pulmonary Disease

被引:3
作者
Kwon, Byoung-Soo [1 ]
Lee, Kyunghoon [2 ]
Kim, Eun-Sun [1 ]
Jun, Sun-Hee [2 ]
Lim, Sung-Yoon [1 ]
Song, Myung-Jin [1 ]
Kim, Yeon-Wook [1 ]
Lee, Yeon-Joo [1 ]
Park, Jong-Sun [1 ]
Cho, Young-Jae [1 ]
Yoon, Ho-Il [1 ]
Lee, Choon-Taek [1 ]
Song, Junghan [2 ]
Lee, Jae-Ho [1 ]
机构
[1] Seoul Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med, Bundang Hosp, 82 Gumi Ro 173 Beon Gil, Seongnam Si 13620, Gyeonggi Do, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si 13620, Gyeonggi Do, South Korea
关键词
nontuberculous mycobacterial; vitamin D; bioavailable; D-BINDING PROTEIN; LUNG-DISEASE; MINERAL METABOLISM; BODY-COMPOSITION; TUBERCULOSIS; ACTIVATION;
D O I
10.3390/nu13082524
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the vitamin D parameters of patients with NTM-PD to those of a healthy control group, and to assess the possible predictive markers for a clinical response. We prospectively enrolled 53 patients with NTM-PD between January 2014 and December 2016. The clinical data and vitamin D indices, including total, free, bioavailable 25-(OH)D, and vitamin D binding protein (VDBP) genotyping, were measured at baseline and six months after enrollment. An external dataset of 226 healthy controls was compared with the NTM-PD group. The mean age of subjects was 53 years; 54.5% were male. The NTM-PD group was older, predominantly female, and had a lower body mass index (BMI) than the controls. The proportion of patients with vitamin D concentration <50 nmol/L was 52.8% in the NTM-PD group and 54.9% in the control group (p = 0.789). The bioavailable 25-(OH)D concentrations of the NTM-PD group and the controls were similar (6.9 nmol/L vs. 7.6 nmol/L, p = 0.280). In the multivariable analysis, bioavailable 25-(OH)D concentrations were associated with NTM-PD, adjusting for age, sex, BMI, and VDBP levels. Bioavailable 25-(OH)D concentrations were significantly associated with susceptibility to NTM-PD, but not with treatment outcomes. Lower bioavailable 25-(OH)D might be a risk factor for NTM-PD.
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页数:10
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