STAT5A and STAT5B-Twins with Different Personalities in Hematopoiesis and Leukemia

被引：50

作者：

Maurer, Barbara ^{[1
]}

Kollmann, Sebastian ^{[1
]}

Pickem, Judith ^{[1
]}

Hoelbl-Kovacic, Andrea ^{[1
]}

Sexl, Veronika ^{[1
]}

机构：

[1] Univ Vet Med, Inst Pharmacol & Toxicol, A-1210 Vienna, Austria

来源：

CANCERS | 2019年 / 11卷 / 11期

基金：

奥地利科学基金会;

关键词：

STAT5A; STAT5B; hematopoietic stem cells; STAT5B(N642H); STAT5 mouse models; BCR-ABL; leukemia; hematopoiesis; SMALL-MOLECULE INHIBITOR; T-CELL HOMEOSTASIS; SIGNAL TRANSDUCER; DNA-BINDING; STEM-CELLS; MAMMARY-GLAND; SERINE PHOSPHORYLATION; LYMPHOID DEVELOPMENT; TRANSCRIPTION; 5B; IN-VIVO;

D O I：

10.3390/cancers11111726

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transcription factors STAT5A and STAT5B have essential roles in survival and proliferation of hematopoietic cells-which have been considered largely redundant. Mutations of upstream kinases, copy number gains, or activating mutations in STAT5A, or more frequently in STAT5B, cause altered hematopoiesis and cancer. Interfering with their activity by pharmacological intervention is an up-and-coming therapeutic avenue. Precision medicine requests detailed knowledge of STAT5A's and STAT5B's individual functions. Recent evidence highlights the privileged role for STAT5B over STAT5A in normal and malignant hematopoiesis. Here, we provide an overview on their individual functions within the hematopoietic system.

引用

页数：23

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