Role of Advanced Glycation End-Products and Other Ligands for AGE Receptors in Thyroid Cancer Progression

被引:6
作者
Bronowicka-Szydelko, Agnieszka [1 ]
Kotyra, Lukasz [1 ]
Lewandowski, Lukasz [1 ]
Gamian, Andrzej [2 ]
Kustrzeba-Wojcicka, Irena [1 ]
机构
[1] Wroclaw Med Univ, Dept Med Biochem, Chalubinskiego 10, PL-50368 Wroclaw, Poland
[2] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Dept Immunol Infect Dis, Weigla 12, PL-53114 Wroclaw, Poland
关键词
AGE; glycation; HMGB1; inflammation; RAGE; thyroid cancer; THYROGLOBULIN MESSENGER-RNA; PERIPHERAL-BLOOD; SODIUM/IODIDE SYMPORTER; TUMOR PROGRESSION; RAGE EXPRESSION; GENE-EXPRESSION; OXIDANT STRESS; RAS MUTATIONS; NADPH OXIDASE; TRANSCRIPTS;
D O I
10.3390/jcm10184084
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To date, thyroid cancers (TCs) remain a clinical challenge owing to their heterogeneous nature. The etiopathology of TCs is associated not only with genetic mutations or chromosomal rearrangements, but also non-genetic factors, such as oxidative-, nitrosative-, and carbonyl stress-related alterations in tumor environment. These factors, through leading to the activation of intracellular signaling pathways, induce tumor tissue proliferation. Interestingly, the incidence of TCs is often coexistent with various simultaneous mutations. Advanced glycation end-products (AGEs), their precursors and receptors (RAGEs), and other ligands for RAGEs are reported to have significant influence on carcinogenesis and TCs progression, inducing gene mutations, disturbances in histone methylation, and disorders in important carcinogenesis-related pathways, such as PI3K/AKT/NF-kB, p21/MEK/MPAK, or JAK/STAT, RAS/ERK/p53, which induce synthesis of interleukins, growth factors, and cytokines, thus influencing metastasis, angiogenesis, and cancer proliferation. Precursors of AGE (such as methylglyoxal (MG)) and selected ligands for RAGEs: AS1004, AS1008, and HMGB1 may, in the future, become potential targets for TCs treatment, as low MG concentration is associated with less aggressive anaplastic thyroid cancer, whereas the administration of anti-RAGE antibodies inhibits the progression of papillary thyroid cancer and anaplastic thyroid cancer. This review is aimed at collecting the information on the role of compounds, engaged in glycation process, in the pathogenesis of TCs. Moreover, the utility of these compounds in the diagnosis and treatment of TCs is thoroughly discussed. Understanding the mechanism of action of these compounds on TCs pathogenesis and progression may potentially be the grounds for the development of new treatment strategies, aiming at quality-of-life improvements.
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页数:19
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