Responding to attraction:: chemotaxis and chemotropism in Dictyostelium and yeast

被引:74
作者
Arkowitz, RA [1 ]
机构
[1] MRC, Mol Biol Lab, Div Cell Biol, Cambridge CB2 2QH, England
关键词
D O I
10.1016/S0962-8924(98)01412-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polarized growth in response to external signals is essential for both the internal organization of cells and generation of complex multicellular structures during development. Oriented growth or movement requires specific detection of an: external cue, reorganization of the cytoskeleton and subsequent growth or movement. Genetic approaches in both the budding yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum have shed light on the molecular and cellular aspects of growth or movement towards an external signal. This review discusses the mechanisms and signalling pathways that enable yeast and Dictyostelium cells to translate external signals into directed growth and movement respectively.
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页码:20 / 27
页数:8
相关论文
共 52 条
[1]  
Akada R, 1996, GENETICS, V143, P103
[2]   A role for Cdc42 in macrophage chemotaxis [J].
Allen, WE ;
Zicha, D ;
Ridley, AJ ;
Jones, GE .
JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1147-1157
[3]   Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B - Evidence that directed migration does not require rapid modulation of signaling at the receptor level [J].
Arai, H ;
Monteclaro, FS ;
Tsou, CL ;
Franci, C ;
Charo, IF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) :25037-25042
[4]   Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B:: Evidence that directed migration is mediated by βγ dimers released by activation of Gαi-coupled receptors [J].
Arai, H ;
Tsou, CL ;
Charo, IF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14495-14499
[5]   CHEMOATTRACTANT SIGNALING AND LEUKOCYTE ACTIVATION [J].
BOKOCH, GM .
BLOOD, 1995, 86 (05) :1649-1660
[6]   IDENTIFICATION OF A GENE NECESSARY FOR CELL-CYCLE ARREST BY A NEGATIVE GROWTH-FACTOR OF YEAST - FAR1 IS AN INHIBITOR OF A G1 CYCLIN, CLN2 [J].
CHANG, F ;
HERSKOWITZ, I .
CELL, 1990, 63 (05) :999-1011
[7]   A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium [J].
Chen, MY ;
Long, Y ;
Devreotes, PN .
GENES & DEVELOPMENT, 1997, 11 (23) :3218-3231
[8]   Signaling through chemoattractant receptors in Dictyostelium [J].
Chen, MY ;
Insall, RH ;
Devreotes, PN .
TRENDS IN GENETICS, 1996, 12 (02) :52-57
[9]   CELL POLARIZATION DIRECTED BY EXTRACELLULAR CUES IN YEAST [J].
CHENEVERT, J .
MOLECULAR BIOLOGY OF THE CELL, 1994, 5 (11) :1169-1175
[10]  
CHENEVERT J, 1994, GENETICS, V136, P1287