Click Chemistry: An Efficient Synthesis of Heterocycles Substituted with Steroids, Saponins, and Digitalis Analogues

被引：33

作者：

Deobald, Anna M. ^{[1
]}

Camargo, Leandro R. S. ^{[1
,2
]}

Alves, Diego ^{[3
]}

Zukerman-Schpector, Julio ^{[2
]}

Correa, Arlene G. ^{[1
]}

Paixao, Marcio W. ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, Lab Sintese Prod Nat, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Fed Sao Carlos, Dept Quim, Lab Cristalografia Estereodinamica & Modelagem Mo, BR-13565905 Sao Carlos, SP, Brazil

[3] Univ Fed Pelotas, Lab Sintese Organica Limpa, BR-96001970 Pelotas, RS, Brazil

来源：

SYNTHESIS-STUTTGART | 2011年 / 24期

基金：

巴西圣保罗研究基金会;

关键词：

click chemistry; 1,2,3-triazole; sugars; steroids; saponins; digitalis; BILE-ACID DIMERS; 1,3-DIPOLAR CYCLOADDITIONS; PRACTICAL SYNTHESIS; FACILE SYNTHESIS; SOLID-PHASE; AZIDE; OLIGONUCLEOTIDES; DERIVATIVES; GLYCOSIDES; LIGATION;

D O I：

10.1055/s-0031-1289606

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been used for the construction of 1,2,3-triazole containing steroids in good to excellent yields. Combination of propargylic glycosides and steroidal azides as reaction partner allowed the synthesis of a privileged class of natural product analogues. The versatility of this protocol makes this chemistry a useful attractive approach for the synthesis of target molecules.

引用

页码：4003 / 4010

页数：8

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