Neurovascular coupling and energy metabolism in the developing brain

被引:78
作者
Kozberg, M. [1 ]
Hillman, E. [1 ,2 ,3 ]
机构
[1] Columbia Univ, New York, NY 10027 USA
[2] Columbia Univ, Kavli Inst Brain Sci, New York, NY 10027 USA
[3] Columbia Univ, Mortimer B Zuckerman Inst Mind Brain & Behav, New York, NY 10027 USA
来源
NEW HORIZONS IN NEUROVASCULAR COUPLING: A BRIDGE BETWEEN BRAIN CIRCULATION AND NEURAL PLASTICITY | 2016年 / 225卷
关键词
Neurovascular coupling; fMRI; Optical imaging; Brain development; Brain metabolism; CEREBRAL-BLOOD-FLOW; RAT VISUAL-CORTEX; NEAR-INFRARED SPECTROSCOPY; RESTING-STATE FMRI; HEMODYNAMIC-RESPONSES; POSTNATAL-DEVELOPMENT; SOMATOSENSORY CORTEX; NEWBORN-INFANTS; NEURAL ACTIVITY; FUNCTIONAL MRI;
D O I
10.1016/bs.pbr.2016.02.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the adult brain, increases in local neural activity are almost always accompanied by increases in local blood flow. However, many functional imaging studies of the newborn and developing human brain have observed patterns of hemodynamic responses that differ from adult responses. Among the proposed mechanisms for the observed variations is that neurovascular coupling itself is still developing in the perinatal brain. Many of the components thought to be involved in actuating and propagating this hemodynamic response are known to still be developing postnatally, including perivascular cells such as astrocytes and pericytes. Both neural and vascular networks expand and are then selectively pruned over the first year of human life. Additionally, the metabolic demands of the newborn brain are still evolving. These changes are highly likely to affect early postnatal neurovascular coupling, and thus may affect functional imaging signals in this age group. This chapter will discuss the literature relating to neurovascular development. Potential effects of normal and aberrant development of neurovascular coupling on the newborn brain will also be explored, as well as ways to effectively utilize imaging techniques that rely on hemodynamic modulation such as fMRI and NIRS in younger populations.
引用
收藏
页码:213 / 242
页数:30
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