HER2 testing in the UK: recommendations for breast and gastric in-situ hybridisation methods

被引：62

作者：

Bartlett, J. M. S. ^{[1
,2
,3
]}

Starczynski, J.

Atkey, Neil ^{[4
]}

Kay, E. ^{[5
]}

O'Grady, A. ^{[5
]}

Gandy, Michael ^{[3
]}

Ibrahim, Merdol ^{[3
]}

Jasani, Bharat ^{[6
]}

Ellis, I. O. ^{[7
]}

Pinder, S. E. ^{[8
]}

Walker, R. A. ^{[9
]}

机构：

[1] Ontario Inst Canc Res, MaRS Ctr, Toronto, ON M5G 0A3, Canada

[2] Endocrine Canc Grp, Edinburgh, Midlothian, Scotland

[3] UCL, UK NEQAS, London, England

[4] Sheffield Childrens NHS Fdn Trust, Sheffield Diagnost Genet Serv, Sheffield, S Yorkshire, England

[5] Beaumont Hosp, Dept Histopathol, Dublin 9, Ireland

[6] Univ Wales Hosp, Cardiff CF4 4XW, S Glam, Wales

[7] Dept Pathol, Nottingham, England

[8] Kings Coll Hosp London, Dept Pathol, London, England

[9] Univ Leicester, Dept Canc Studies, Leicester, Leics, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 64卷 / 08期

关键词：

QUALITY-ASSURANCE; FISH; AMPLIFICATION; CANCER; IMMUNOHISTOCHEMISTRY; CHROMOSOME-17; MULTICENTER; CARCINOMAS; TAMOXIFEN; RECEPTOR;

D O I：

10.1136/jcp.2011.089847

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

These guidelines supplement existing guidelines on HER2 testing by immunohistochemistry and in-situ hybridisation(ISH) methods in the UK. They provide a specific focus on aspects of guidance relevant to HER2 ISH testing methods, both fluorescent and chromogenic. They are formulated to give advice on methodology, interpretation and quality control for ISH-based testing of HER2 status in common tumour types, including both breast and gastric tumours. The aim is to ensure that all ISH-based testing is accurate, reliable and timely.

引用

页码：649 / 653

页数：5

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