Thrombocytopenia: a rare adverse event of an anti-IL-1 RA treatment in an adult auto-inflammatory syndrome

被引：0
作者：
Brevet, P. [1 ]
Curie, A. [2 ]
Princivil, C. [3 ]
Zarnitsky, C. [3 ]
Boulay, C. [4 ]
Alcaix, D. [3 ]
机构：
[1] CHU Rouen, Serv Rhumatol, 1 Rue Germont, Rouen 76031, France
[2] CHU Rouen, Serv Med Interne, 1 Rue Germont, Rouen 76031, France
[3] Le Havre Hop Monod, Serv Rhumatol, 29 Ave Pierre Mendes France, Montivilliers 76290, France
[4] CHU Rouen, Ctr Pharmacovigilance, 1 Rue Germont, Rouen 76031, France
来源：
REVUE DE MEDECINE INTERNE | 2020年 / 41卷 / 05期
关键词：
Anakinra; Anti-IL-1RA; Auto-inflammatory syndrome; IL-1; Drug-induced immune thrombocytopenia; INTERLEUKIN-1 RECEPTOR ANTAGONIST; RHEUMATOID-ARTHRITIS; ANAKINRA; SAFETY; CLASSIFICATION; EFFICACY; CRITERIA;
D O I：
10.1016/j.revmed.2019.11.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction. - Anakinra is an anti-IL-1RA targeting IL-1 beta with a central role in the occurrence of auto-inflammatory diseases. Its use is not without risk. Case report. - We report a case of late onset auto-inflammatory syndrome treated with anti-IL-1RA whose progression was marked by deep isolated thrombocytopenia, rapidly regressive after discontinuation of anakinra. Conclusion. - Immuno-allergic thrombocytopenia to anakinra is a rare, but serious adverse event. (C) 2019 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：343 / 345
页数：3
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