Pregnancy-associated cervical cancer: Obstetric outcomes

Objective. Describe the obstetric outcomes among women in California with pregnancy associated cervical cancer. Methods. Cases were identified utilizing computer-linked infant birth/death certificates, discharge records, and cancer registry files, and then assigned to a prenatal or post-partum cancer diagnosis group. Outcomes included cesarean delivery, hospitalizations, birth weight, prematurity, and infant mortality. Results. Among 434 cases identified, those diagnosed prenatally ( 136 cases) had higher rates of cesarean section ( odds ratio 3.7; 95% CI 2.6, 5.2), hospitalization 45 days ( maternal: odds ratio 14.1; 95% CI 9.2, 21.5 neonatal: odds ratio 5.2; 95% CI 3.6, 7.5), low birth weight ( LBW) ( odds ratio 5.5; 95% CI 3.7, 8.1), very LBW ( odds ratio 6.9; 95% CI 3.7, 12.8), prematurity ( odds ratio 4.7; 95% CI 3.2, 6.7), and fetal deaths ( odds ratio 5.5; 95% CI 2.0, 14.8) compared to non-cancer pregnant controls. Very LBW ( odds ratio 2.6; 95% CI 1.4, 4.8), prematurity ( odds ratio 1.5; 95% CI 1.1, 2.1), and fetal death rates ( odds ratio 3.0; 95% CI 1.2, 7.4) remained elevated among those diagnosed post-partum. No neonatal deaths were attributable to elective premature delivery. Conclusions. We observed higher rates of fetal death and spontaneous prematurity among women with pregnancy-associated cervical cancer.