Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses

被引：20

作者：

Joy, J. P. ^{[1
]}

Coulter, C. V. ^{[1
]}

Duffull, S. B. ^{[1
]}

Isbister, G. K. ^{[2
,3
]}

机构：

[1] Univ Otago, Sch Pharm, Dunedin, New Zealand

[2] Calvary Mater Newcastle Hosp, Dept Clin Toxicol, Newcastle, NSW, Australia

[3] Univ Newcastle, Discipline Clin Pharmacol, Newcastle, NSW 2300, Australia

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 90卷 / 02期

关键词：

HEART-RATE CORRECTION; PROLONGATION;

D O I：

10.1038/clpt.2011.107

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Electrocardiograms (ECGs) from a case series of 86 amisulpride overdose events in 66 patients were reviewed for abnormal QT intervals and torsade de pointes (TdP). Eight patients exhibited TdP. In this investigative case series, the magnitude of prolongation of the QT interval was a stronger predictor of TdP than the mere presence of a prolongation per se.

引用

页码：243 / 245

页数：3

共 12 条

[1]

Bazett HC, 1920, HEART-J STUD CIRC, V7, P353

[2] Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram [J].

Chan, A. ;

Isbister, G. K. ;

Kirkpatrick, C. M. J. ;

Dufful, S. B. .

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2007, 100 (10) :609-615

[3] Variability of heart rate correction methods for the QT interval [J].

Desai, M ;

Li, L ;

Desta, Z ;

Malik, M ;

Flockhart, D .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 55 (06) :511-517

[4]

Fridericia LS., 1920, Acta Med Scand, V53, P469, DOI [10.1111/j.0954-6820.1920.tb18267.x, DOI 10.1111/J.0954-6820.1920.TB18266.X, 10.1111/j.0954-6820.1920.tb18266.x]

[5] Optimum formulae for heart rate correction of the QT interval [J].